Effects of turmeric extract supplementation on the lipid and lipoprotein subfraction profile in hemodialysis patients: A randomised, double-blind, crossover and controlled trial.

Autor: Alvarenga L; Graduate Program in Biological Sciences-Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil., Cardozo LFMF; Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, Brazil., Ribeiro-Alves M; HIV/AIDS Clinical Research Center, National Institute of Infectology (INI/Fiocruz), Rio de Janeiro, State of Rio de Janeiro, Brazil., Damasceno NRT; Department of Nutrition, Faculty of Public Health, University of São Paulo (FSP-USP), São Paulo, Brazil., Berretta AA; Research, Development, and Innovation Department, Apis Flora Indl. Coml. Ltda., Ribeirão Preto, São Paulo, Brazil., Lima JA; Research, Development, and Innovation Department, Apis Flora Indl. Coml. Ltda., Ribeirão Preto, São Paulo, Brazil., Khosla P; Department of Nutrition and Food Science, Wayne State University, Detroit, Michigan, USA., Fouque D; Department of Nephrology, Centre Hopitalier Lyon Sud, INSERM 1060, CENS, Université de Lyon, Lyon, France., Mafra D; Graduate Program in Biological Sciences-Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2023 Aug; Vol. 37 (8), pp. 3424-3437. Date of Electronic Publication: 2023 Apr 12.
DOI: 10.1002/ptr.7814
Abstrakt: Dyslipidemia is common in patients with chronic kidney disease. Curcumin, a bioactive polyphenol from Curcuma longa, can improve lipid profile. This study aims to analyze the effects of Curcuma Longa extract supplementation on lipid profile and lipoprotein subfractions in hemodialysis (HD) patients. This is a longitudinal, double-blind, washout-period randomized clinical trial. The patients were randomized into two groups: the curcumin group (n = 10) (orange and carrot juice with 2.5 g of Curcuma Longa extract) and the control group (n = 11) (juice without curcumin) 3x/w during HD sessions for 3 months. After the washout period, patients continued the supplementation as a crossover for the same period. The lipid profile was measured using enzymatic assays. The high-density lipoprotein and low-density lipoprotein subfractions analyses were performed using LipoprintTM. In the curcumin group, the triglyceride values tended to decrease with a different triglyceride variation between the pre and post-intervention for the control and curcumin groups of 38.5 (19.8) mg/dL (p = 0.06). There was no statistical difference in the others parameters. In conclusion, Curcuma longa extract may be a good nutritional strategy to reduce triglyceride plasma levels in hemodialysis patients, but it seems ineffective for the other parameter.
(© 2023 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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