Resting-State Functional Connectivity Differences Following Experimental Manipulation of the Orbitofrontal Cortex in Two Directions via Theta-Burst Stimulation.

Autor:	Price RB; Department of Psychiatry, University of Pittsburgh.; Department of Psychology, University of Pittsburgh., Ferrarelli F; Department of Psychiatry, University of Pittsburgh., Hanlon C; Department of Cancer Biology, Wake Forest University., Gillan CM; Department of Psychology, Trinity College Dublin., Kim T; Department of Radiology, University of Pittsburgh., Siegle GJ; Department of Psychiatry, University of Pittsburgh., Wallace ML; Department of Psychiatry, University of Pittsburgh., Renard M; Department of Psychiatry, University of Pittsburgh., Kaskie R; Department of Psychiatry, University of Pittsburgh., Degutis M; Department of Psychiatry, University of Pittsburgh., Wears A; Department of Psychiatry, University of Pittsburgh., Brown V; Department of Psychiatry, University of Pittsburgh., Rengasamy M; Department of Psychiatry, University of Pittsburgh., Ahmari SE; Department of Psychiatry, University of Pittsburgh.
Jazyk:	angličtina
Zdroj:	Clinical psychological science : a journal of the Association for Psychological Science [Clin Psychol Sci] 2023 Jan; Vol. 11 (1), pp. 77-89. Date of Electronic Publication: 2022 Jul 29.
DOI:	10.1177/21677026221103136
Abstrakt:	Compulsive behaviors (CBs) have been linked to orbitofrontal cortex (OFC) function in animal and human studies. However, brain regions function not in isolation but as components of widely distributed brain networks-such as those indexed via resting-state functional connectivity (RSFC). Sixty-nine individuals with CB disorders were randomized to receive a single session of neuromodulation targeting the left OFC-intermittent theta-burst stimulation (iTBS) or continuous TBS (cTBS)-followed immediately by computer-based behavioral "habit override" training. OFC seeds were used to quantify RSFC following iTBS and following cTBS. Relative to cTBS, iTBS showed increased RSFC between right OFC (Brodmann's area 47) and other areas, including dorsomedial prefrontal cortex (dmPFC), occipital cortex, and a priori dorsal and ventral striatal regions. RSFC connectivity effects were correlated with OFC/frontopolar target engagement and with subjective difficulty during habit-override training. Findings help reveal neural network-level impacts of neuromodulation paired with a specific behavioral context, informing mechanistic intervention development. Competing Interests: Declaration of Conflicting Interests The author(s) declared that there were no conflicts of interest with respect to the authorship or the publication of this article.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu