Improvement in radiation techniques for locally advanced cervical cancer during the last two decades.

Autor:	Sagae S; Women's Medical Center, Tokeidai Memorial Hospital, Sapporo, Hokkaido, Japan str-sagae@outlook.jp., Toita T; Radiation Therapy Center, Okinawa Chubu Hospital, Uruma, Okinawa, Japan., Matsuura M; Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Hokkaido, Japan., Saito M; Women's Medical Center, Tokeidai Memorial Hospital, Sapporo, Hokkaido, Japan., Matsuda T; Women's Medical Center, Tokeidai Memorial Hospital, Sapporo, Hokkaido, Japan., Sato N; Women's Medical Center, Tokeidai Memorial Hospital, Sapporo, Hokkaido, Japan., Shimizu A; Women's Medical Center, Tokeidai Memorial Hospital, Sapporo, Hokkaido, Japan., Endo T; Women's Medical Center, Tokeidai Memorial Hospital, Sapporo, Hokkaido, Japan.; Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Hokkaido, Japan., Fujii M; Women's Medical Center, Tokeidai Memorial Hospital, Sapporo, Hokkaido, Japan., Gaffney DK; Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA., Small W Jr; Department of Radiation Oncology, Loyola University Chicago, Stritch School of Medicine, Cardinal Bernardin Cancer Center, Maywood, Illinois, USA.
Jazyk:	angličtina
Zdroj:	International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2023 Aug 07; Vol. 33 (8), pp. 1295-1303. Date of Electronic Publication: 2023 Aug 07.
DOI:	10.1136/ijgc-2022-004230
Abstrakt:	Since the National Cancer Institute (NCI) alert of concurrent chemoradiotherapy, radiotherapy has been changed from external beam radiotherapy plus brachytherapy to platinum-based concurrent chemoradiotherapy. Therefore, concurrent chemoradiotherapy plus brachytherapy has become a standard treatment for locally advanced cervical cancer. Simultaneously, definitive radiotherapy has been changed gradually from external beam radiotherapy plus low-dose-rate intracavitary brachytherapy to external beam radiotherapy plus high-dose-rate intracavitary brachytherapy. Cervix cancer is uncommon in developed countries; hence, international collaborations have been critical in large-scale clinical trials. The Cervical Cancer Research Network (CCRN), created from the Gynecologic Cancer InterGroup (GCIG), has investigated various concurrent chemotherapy regimens and sequential methods of radiation and chemotherapy. Most recently, many clinical trials of combining immune checkpoint inhibitors with radiotherapy have been ongoing for sequential or concurrent settings. During the last decade, the method of standard radiation therapy has changed from three-dimensional conformal radiation therapy to intensity-modulated radiation therapy for external beam radiotherapy and from two-dimensional to three-dimensional image-guided approaches for brachytherapy. Recent improvements include stereotactic ablative body radiotherapy and MRI-guided linear accelerator (MRI-LINAC) using adaptive radiotherapy. Here we review the current progress of radiation therapy during the last two decades. Competing Interests: Competing interests: None declared. (© IGCS and ESGO 2023. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
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