Association Between Parameters of Cortisol Metabolism, Biomarkers of Minerals (Zinc, Selenium, and Magnesium), and Insulin Resistance and Oxidative Stress in Women with Obesity.

Autor: Morais JBS; Department of Nutrition, Federal University of Piaui, Teresina, Brazil., Cruz KJC; Department of Nutrition, Federal University of Piaui, Teresina, Brazil., de Oliveira ARS; Department of Nutrition, Federal University of Piaui, Teresina, Brazil., Cardoso BEP; Department of Nutrition, Federal University of Piaui, Teresina, Brazil., da Silva Dias TM; Department of Nutrition, Federal University of Piaui, Teresina, Brazil., de Sousa Melo SR; Department of Nutrition, Federal University of Piaui, Teresina, Brazil., Dos Santos LR; Department of Nutrition, Federal University of Piaui, Teresina, Brazil., Severo JS; Department of Nutrition, Federal University of Piaui, Teresina, Brazil., de Freitas ST; Federal University of Pará, Belém, Brazil., Henriques GS; School of Nursing, Federal University, Minas Gerais, Belo Horizonte, Brazil., da Silva MTB; Institute of Biomedical Sciences Abel Salazar, Center for Drug Discovery and Innovative Medicines, Laboratory of Physiology, Department of Immuno-Physiology and Pharmacology, University of Porto, Porto, Portugal., Oliveira FE; Clinical Laboratory, Teresina, Piauí, Brazil., do Nascimento Marreiro D; Department of Nutrition, Federal University of Piaui, Teresina, Brazil. dilina.marreiro@ufpi.edu.br.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2023 Dec; Vol. 201 (12), pp. 5677-5691. Date of Electronic Publication: 2023 Apr 11.
DOI: 10.1007/s12011-023-03639-7
Abstrakt: This is a cross-sectional study with women divided into a group of those with obesity (n = 80) and a control group (n = 94). Statistical analysis was conducted using the SPSS program. There were high values of GPx and TBARS and reduced values of SOD in women with obesity compared to the control group. Obese women showed increased concentrations of cortisol in serum and urine as well as hypozincemia, hyposelenemia, and hypomagnesemia and increased urinary excretion of these minerals. There was a negative correlation between the cortisol/cortisone ratio and erythrocyte zinc and selenium concentrations and a significant positive correlation between GPx and SOD activity and erythrocyte and plasma concentrations of zinc and selenium. The results of the study suggest the influence of adiposity on the increase in cortisol concentrations and the role of this hormone in the compartmentalization of the minerals zinc, selenium, and magnesium. However, the association study does not allow identifying the impact of such action on the antioxidant defense system and insulin sensitivity.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: