Firing patterns of ventral hippocampal neurons predict the exploration of anxiogenic locations.
| Autor: | Malagon-Vina H; Division of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria., Ciocchi S; Division of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria.; Laboratory of Systems Neuroscience, Department of Physiology, University of Bern, Bern, Switzerland., Klausberger T; Division of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria. |
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| Jazyk: | angličtina |
| Zdroj: | ELife [Elife] 2023 Apr 11; Vol. 12. Date of Electronic Publication: 2023 Apr 11. |
| DOI: | 10.7554/eLife.83012 |
| Abstrakt: | The ventral hippocampus (vH) plays a crucial role in anxiety-related behaviour and vH neurons increase their firing when animals explore anxiogenic environments. However, if and how such neuronal activity induces or restricts the exploration of an anxiogenic location remains unexplained. Here, we developed a novel behavioural paradigm to motivate rats to explore an anxiogenic area. Male rats ran along an elevated linear maze with protective sidewalls, which were subsequently removed in parts of the track to introduce an anxiogenic location. We recorded neuronal action potentials during task performance and found that vH neurons exhibited remapping of activity, overrepresenting anxiogenic locations. Direction-dependent firing was homogenised by the anxiogenic experience. We further showed that the activity of vH neurons predicted the extent of exploration of the anxiogenic location. Our data suggest that anxiety-related firing does not solely depend on the exploration of anxiogenic environments, but also on intentions to explore them. Competing Interests: HM, SC, TK No competing interests declared (© 2023, Malagon-Vina et al.) |
| Databáze: | MEDLINE |
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