Effect of altitude on ticagrelor-induced dyspnea in patients with acute coronary syndrome.

Autor: Kocabay G; Kartal Kosuyolu Heart and Research Hospital, Istanbul, Turkey., Kivrak T; Firat University, Department of Cardiology, Elazig, Turkey., Karaca O; Firat University, Department of Cardiology, Elazig, Turkey., Karasu M; Firat University, Department of Cardiology, Elazig, Turkey., Kaya H; Cumhuriyet University, Department of Cardiology, Sivas, Turkey., Kanar B; Marmara University, Department of Cardiology, Istanbul, Turkey., Orscelik O; Mersın University, Department of Cardiology, Mersin, Turkey., Kobat MA; Firat University, Department of Cardiology, Elazig, Turkey., Yilmaz MB; Dokuz Eylül University, Department of Cardiology, Izmir, Turkey.
Jazyk: angličtina
Zdroj: The Journal of international medical research [J Int Med Res] 2023 Apr; Vol. 51 (4), pp. 3000605211065932.
DOI: 10.1177/03000605211065932
Abstrakt: Objective: This study aimed to define the association between altitude and ticagrelor-associated dyspnea in patients with acute coronary syndrome (ACS).
Methods: We studied consecutive patients with de novo ACS who were admitted to two centers at a low altitude (18 and 25 m, n = 65) and two centers at a high altitude (1313 and 1041 m, n = 136). We managed them with ticagrelor between May 2017 and September 2017. Patients with ACS underwent an interventional procedure within <90 minutes in those with ST elevation and within <3 hours in those without ST elevation. We recorded the incidence of dyspnea in patients with ACS receiving ticagrelor therapy.
Results: The mean age was 59.5 ± 10 years, and the mean ejection fraction was 43% ± 18%. A total of 110 (56.7%) patients had ST elevation and 84 (43.3%) did not. There were no significant differences in cardiac risk factors, concurrent medications, or procedural variables between the two groups. Dyspnea developed during hospitalization in 53 (38%) patients from high-altitude centers and in 13 (20%) patients from low-altitude centers (66 patients represented 32% of the total ACS cohort).
Conclusions: Dyspnea is a common multifactorial symptom in patients following development of ACS. Ticagrelor-induced dyspnea appears to be associated with altitude.
Databáze: MEDLINE
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