Relationship between empirical dietary inflammatory potential and myocardial infarction.

Autor:	Mostafa MA; Epidemiological Cardiology Research Center (EPICARE), Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: moh.adel.mostafa@gmail.com., Skipina TM; Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: tskipina@wakehealth.edu., Shalash OA; Epidemiological Cardiology Research Center (EPICARE), Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: mimishalash@hotmail.com., Soliman EZ; Epidemiological Cardiology Research Center (EPICARE), Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: esoliman@wakehealth.edu.
Jazyk:	angličtina
Zdroj:	The American journal of the medical sciences [Am J Med Sci] 2023 Jul; Vol. 366 (1), pp. 44-48. Date of Electronic Publication: 2023 Apr 08.
DOI:	10.1016/j.amjms.2023.04.004
Abstrakt:	Background: Inflammation plays an important role in developing myocardial infarction (MI). This study examined whether a proinflammatory diet is associated with increased risk of myocardial infarction. Methods: This analysis included 7,134 participants (60.3 ± 13.6 years; 51.8% females) from the third National Health and Nutrition Examination (NHANES-III). The proinflammatory diet was assessed using the empirical dietary inflammatory potential (EDIP) score, calculated from the Food Frequency Questionnaire. MI was defined from electrocardiograms (ECGs) using the Minnesota ECG Classification. The cross-sectional association between levels of EDIP modeled as tertiles and per 1-standard deviation (1-SD) increase in separate models with the risk of MI using multivariable logistic regression analysis. Results: Participants with MI (n=230 (3.2%)) had higher levels of EDIP scores compared to those without MI (0.148 ± 0.241 score units vs. 0.106 ± 0.256 score units, respectively; p=0.01). In multivariable-adjusted models, each 1-SD (0.256 score unit) increase in EDIP was associated with 20% increased odds of MI (OR (95% CI); 1.20 (1.05 to 1.38)). Odds of MI increased as the levels of EDIP tertiles increased, indicating a dose-response relationship (OR (95% CI); 1,41 (1.0 to 1.99) and 1.48 (1.05 to 2.09), respectively). These results were consistent among subgroups of the participants stratified by hypertension, obesity, diabetes, and hyperlipidemia, but effect modification by smoking status was observed (interaction p-value=0.04). Conclusions: Dietary patterns with high proinflammatory properties are associated with an increased risk of MI. Advocating for low proinflammatory dietary patterns could be an approach for preventing coronary heart disease. Competing Interests: Declaration of Competing Interests None declared. (Copyright © 2023 Southern Society for Clinical Investigation. All rights reserved.)
Databáze:	MEDLINE
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