Distinct neural mechanisms for heading retrieval and context recognition in the hippocampus during spatial reorientation.

Autor:	Gagliardi CM; Department of Neuroscience, Development, and Regenerative Biology, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX 78249, USA.; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52245, USA., Normandin ME; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52245, USA., Keinath AT; Department of Psychiatry, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, Verdun, QC, H4H 1RS, Canada., Julian JB; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA., Lopez MR; Department of Neuroscience, Development, and Regenerative Biology, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX 78249, USA.; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52245, USA., Ramos-Alvarez MM; Psychology Department, University of Jaen, Campus Las Lagunillas, Jaen 23071, Spain., Epstein RA; Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA., Muzzio IA; Department of Neuroscience, Development, and Regenerative Biology, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX 78249, USA.; Department of Psychiatry, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, Verdun, QC, H4H 1RS, Canada.; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.; Psychology Department, University of Jaen, Campus Las Lagunillas, Jaen 23071, Spain.; Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52245, USA.
Jazyk:	angličtina
Zdroj:	Research square [Res Sq] 2023 Mar 31. Date of Electronic Publication: 2023 Mar 31.
DOI:	10.21203/rs.3.rs-2724785/v1
Abstrakt:	Reorientation, the process of regaining one's bearings after becoming lost, requires identification of a spatial context (context recognition) and recovery of heading direction within that context (heading retrieval). We previously showed that these processes rely on the use of features and geometry, respectively. Here, we examine reorientation behavior in a task that creates contextual ambiguity over a long timescale to demonstrate that mice learn to combine both featural and geometric cues to recover heading with experience. At the neural level, most CA1 neurons persistently align to geometry, and this alignment predicts heading behavior. However, a small subset of cells shows feature-sensitive place field remapping, which serves to predict context. Efficient heading retrieval and context recognition require integration of featural and geometric information in the active network through rate changes. These data illustrate how context recognition and heading retrieval are coded in CA1 and how these processes change with experience. Competing Interests: Declaration of Interests: The authors declare no competing interests. Competing Interests: The authors do not have conflict of interests.
Databáze:	MEDLINE
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