Impact of Mesoporous Silica Functionalization Fine-Tuning on Antibiotic Uptake/Delivery and Bactericidal Activity.

Autor: Bouchmella K; Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), P.O. Box 6192, Campinas CEP 13083-970, SP, Brazil.; Chemistry Institute (IQ), Universidade Estadual de Campinas (UNICAMP), P.O. Box 6154, Campinas CEP 13083-970, SP, Brazil.; ICGM, University Montpellier, CNRS, ENSCM, 34095 Montpellier, France., Lion Q; Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), P.O. Box 6192, Campinas CEP 13083-970, SP, Brazil.; Interdisciplinary Cluster for Applied Genoproteomics, University of Liege, Liege 4000, Belgium.; Laboratory of Medical Chemistry, University of Liege, Liege 4000, Belgium.; GIGA Stem Cells, University of Liege, Liege 4000, Belgium., Gervais C; LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris, Sorbonne Université, 4 place Jussieu, 75252 Paris Cedex 05, France., Cardoso MB; Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), P.O. Box 6192, Campinas CEP 13083-970, SP, Brazil.; Chemistry Institute (IQ), Universidade Estadual de Campinas (UNICAMP), P.O. Box 6154, Campinas CEP 13083-970, SP, Brazil.
Jazyk: angličtina
Zdroj: ACS omega [ACS Omega] 2023 Mar 22; Vol. 8 (13), pp. 12154-12164. Date of Electronic Publication: 2023 Mar 22 (Print Publication: 2023).
DOI: 10.1021/acsomega.2c08065
Abstrakt: The mesoporous SBA-15 material was surface-functionalized with amino and carboxylic acid groups and used as a platform to investigate the interaction of these chemical groups with tetracycline, kanamycin, and ampicillin antibiotics. The interactions between the antibiotic and the functionalized surfaces were characterized using two-dimensional 1 H- 13 C HETCOR CP MAS and FTIR spectroscopy and indicated that -COO - NH 3 + bondings had been formed between chemical groups on the silica surface and drug molecules. The surface modification resulted in higher kanamycin and ampicillin loadings and a slow-release rate, and all synthesized systems showed antibacterial activity against susceptible Escherichia coli bacteria. Almost total death of bacteria was obtained using a few ppm of tetracycline- and kanamycin-loaded systems, whereas the ampicillin-loaded one showed lower bactericidal activity than free ampicillin.
Competing Interests: The authors declare no competing financial interest.
(© 2023 The Authors. Published by American Chemical Society.)
Databáze: MEDLINE
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