Congenital Adrenal Hyperplasia and Human Leukocyte Antigen B: A Meta-Analysis.
| Autor: | Thibaut D; Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA., Walter MR; Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA., McGonegal C; Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA., Daniel R; Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA., Goodman J; Obstetrics and Gynecology, Lake Erie College of Osteopathic Medicine, Bradenton, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Mar 08; Vol. 15 (3), pp. e35900. Date of Electronic Publication: 2023 Mar 08 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.35900 |
| Abstrakt: | The link between specific human leukocyte antigen (HLA)-B genes and congenital adrenal hyperplasia (CAH) has been a subject of interest. This study investigates the association between specific HLA-B haplotypes and CAH through a meta-analysis. Google Scholar was used as a database. Articles were included if the research was conducted between 1970 and 2022, was not a meta-analysis, and had odds ratios or enough data points to calculate an odds ratio. The National Institutes of Health (NIH) quality assessment tool of case-control studies was used to evaluate the risk of bias in individual studies, and MetaXL was used to generate data and create a forest plot for analysis. Twelve studies met the selection criteria and were included in the study (641 patients and 3,614 controls). Two HLA-B haplotypes showed increased odds of CAH compared to controls: B14 (OR=3.81; 95%CI=2.88, 5.05; I 2 =3%) and B35 (OR=1.88; 95%CI=1.22, 2.90; I 2 =25%). All other HLAs either showed no significant effect or had high heterogeneity. The results suggest that specific HLA-B haplotypes have increased odds of developing CAH, specifically B14 and B35. These findings may prove helpful in the pre- and post-natal diagnosis of CAH as well as the identification of carriers and prediction of patient prognosis. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Thibaut et al.) |
| Databáze: | MEDLINE |
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