Combined femoral and acetabular version and synovitis are associated with dGEMRIC scores in people with femoroacetabular impingement (FAI) syndrome.

Autor: Murphy NJ; The University of Sydney, Sydney Musculoskeletal Health and the Kolling Institute, Faculty of Medicine and Health and the Northern Sydney Local Health District, Sydney, Australia.; Department of Orthopaedic Surgery, John Hunter Hospital, New Lambton Heights, Australia., Eyles J; The University of Sydney, Sydney Musculoskeletal Health and the Kolling Institute, Faculty of Medicine and Health and the Northern Sydney Local Health District, Sydney, Australia.; Department of Rheumatology, Royal North Shore Hospital, St Leonards, Australia., Spiers L; Department of Physiotherapy, Centre for Health, Exercise and Sports Medicine, University of Melbourne, Melbourne, Australia., Davidson EJ; Department of Radiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia., Linklater JM; Castlereagh Imaging St Leonards, St Leonards, Australia., Kim YJ; Department of Orthopedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA., Hunter DJ; The University of Sydney, Sydney Musculoskeletal Health and the Kolling Institute, Faculty of Medicine and Health and the Northern Sydney Local Health District, Sydney, Australia.; Department of Rheumatology, Royal North Shore Hospital, St Leonards, Australia.
Jazyk: angličtina
Zdroj: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2023 Nov; Vol. 41 (11), pp. 2484-2494. Date of Electronic Publication: 2023 Apr 12.
DOI: 10.1002/jor.25568
Abstrakt: This study sought to explore, in people with symptoms, signs and imaging findings of femoroacetabular impingement (FAI syndrome): (1) whether more severe labral damage, synovitis, bone marrow lesions, or subchondral cysts assessed on magnetic resonance imaging (MRI) were associated with poorer cartilage health, and (2) whether abnormal femoral, acetabular, and/or combined femoral and acetabular versions were associated with poorer cartilage health. This cross-sectional study used baseline data from the 50 participants with FAI syndrome in the Australian FASHIoN trial (ACTRN12615001177549) with available dGEMRIC scans. Cartilage health was measured using delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) score sampled at the chondrolabral junction on three midsagittal slices, at one acetabular and one femoral head region of interest on each slice, and MRI features were assessed using the Hip Osteoarthritis MRI Score. Analyses were adjusted for alpha angle and body mass index, which are known to affect dGEMRIC score. Linear regression assessed the relationship with the dGEMRIC score of (i) selected MRI features, and (ii) femoral, acetabular, and combined femoral and acetabular versions. Hips with more severe synovitis had worse dGEMRIC scores (partial η 2  = 0.167, p = 0.020), whereas other MRI features were not associated. A lower combined femoral and acetabular version was associated with a better dGEMRIC score (partial η 2  = 0.164, p = 0.021), whereas isolated measures of femoral and acetabular version were not associated. In conclusion, worse synovitis was associated with poorer cartilage health, suggesting synovium and cartilage may be linked to the pathogenesis of FAI syndrome. A lower combined femoral and acetabular version appears to be protective of cartilage health at the chondrolabral junction.
(© 2023 The Authors. Journal of Orthopaedic Research® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.)
Databáze: MEDLINE
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