Epidemiology and genetics of early onset colorectal cancer-African overview with a focus on Ethiopia.

Autor:	Anugwom C; Department of Medicine, University of Minnesota, Minneapolis, MN, USA; HealthPartners Digestive Care, Saint Paul, MN, USA., Braimoh G; Hennepin Healthcare, Minneapolis, MN, USA., Sultan A; College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Johnson WM; Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Debes JD; Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Hennepin Healthcare, Minneapolis, MN, USA. Electronic address: debes003@umn.edu., Mohammed A; College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. Electronic address: absam2jk@gmail.com.
Jazyk:	angličtina
Zdroj:	Seminars in oncology [Semin Oncol] 2023 Feb-Apr; Vol. 50 (1-2), pp. 28-33. Date of Electronic Publication: 2023 Mar 31.
DOI:	10.1053/j.seminoncol.2023.03.007
Abstrakt:	Colorectal cancer (CRC) is a common cause of cancer-related death worldwide, with high rates of late diagnosis and increased mortality in sub-Saharan Africa. Furthermore, there is an alarming uptrend in the incidence of early onset colorectal cancer (EOCRC) across the globe, thus necessitating the need for early screening in general and special populations. There is, however, limited data available on the incidence and genetic characteristics of EOCRC from resource-poor countries, particularly Africa. Moreover, there is lack of clarity if recommendations and mechanisms proposed based on data from resource-rich countries applies to other regions of the world. In this review, we appraise the literature on EOCRC, its overall incidence, and genetic components as it pertains to sub-Saharan Africa. In addition, we highlight epidemiologic and epigenetic findings of our EOCRC cohort in Ethiopia. (Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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