Sebaceous carcinoma epidemiology, associated malignancies and Lynch/Muir-Torre syndrome screening in England from 2008 to 2018.

Autor: Cook S; Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom., Pethick J; National Disease Registration Service (NDRS), NHS Digital, London, United Kingdom., Kibbi N; Department of Dermatology, Stanford University School of Medicine, Stanford, California., Hollestein L; Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; Department of Research, Netherlands Comprehensive Cancer Center (IKNL), Utrecht, The Netherlands., Lavelle K; National Disease Registration Service (NDRS), NHS Digital, London, United Kingdom., de Vere Hunt I; Department of Dermatology, Stanford University School of Medicine, Stanford, California., Turnbull C; National Disease Registration Service (NDRS), NHS Digital, London, United Kingdom., Rous B; National Disease Registration Service (NDRS), NHS Digital, London, United Kingdom., Husain A; Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom., Burn J; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Lüchtenborg M; National Disease Registration Service (NDRS), NHS Digital, London, United Kingdom; Centre for Cancer, Society & Public Health, Comprehensive Cancer Centre, King's College London, London, United Kingdom., Santaniello F; National Disease Registration Service (NDRS), NHS Digital, London, United Kingdom; Health Data Insight, Cambridge, United Kingdom., McRonald F; National Disease Registration Service (NDRS), NHS Digital, London, United Kingdom., Hardy S; National Disease Registration Service (NDRS), NHS Digital, London, United Kingdom., Linos E; Department of Dermatology, Stanford University School of Medicine, Stanford, California., Venables Z; National Disease Registration Service (NDRS), NHS Digital, London, United Kingdom; Department of Dermatology, Norfolk and Norwich University Hospital, Norwich, United Kingdom; Norwich Medical School, University of East Anglia, Norwich, United Kingdom., Rajan N; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom. Electronic address: neil.rajan@ncl.ac.uk.
Jazyk: angličtina
Zdroj: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2023 Dec; Vol. 89 (6), pp. 1129-1135. Date of Electronic Publication: 2023 Apr 07.
DOI: 10.1016/j.jaad.2023.03.046
Abstrakt: Background: Sebaceous carcinomas (SC) may be associated with the cancer predisposition syndrome Muir-Torre/Lynch syndrome (MTS/LS), identifiable by SC mismatch repair (MMR) screening; however, there is limited data on MMR status of SC.
Objective: To describe the epidemiology of SC, copresentation of other cancers, and population level frequency of MMR screening in SC.
Methods: A population-based retrospective cohort study of SC patients in the National Cancer Registration and Analysis Service in England.
Results: This study included 1077 SC cases (739 extraocular, 338 periocular). Age-standardized incidence rates (ASIR) were higher in men compared with women, 2.74 (95% CI, 2.52-9.69) per 1,000,000 person-years for men versus 1.47 person-years (95% CI, 1.4-1.62) for women. Of the patients, 19% (210/1077) developed at least one MTS/LS-associated malignancy. MMR immunohistochemical screening was performed in only 20% (220/1077) of SC tumors; of these, 32% (70/219) of tumors were MMR deficient.
Limitations: Retrospective design.
Conclusions: Incorporation of MMR screening into clinical practice guidelines for the management of SC will increase the opportunity for MTS/LS diagnoses, with implications for cancer surveillance, chemoprevention with aspirin, and immunotherapy treatment targeted to MTS/LS cancers.
Competing Interests: Conflicts of interest None disclosed.
(Copyright © 2023 American Academy of Dermatology, Inc. All rights reserved.)
Databáze: MEDLINE
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