Impact of porous microsponges in minimizing myotoxic side effects of simvastatin.

Autor: Ali AU; Department of Pharmaceutics, Faculty of Pharmacy, Merit University, Sohag, Egypt. aasuoffi@hotmail.com., Abd-Elkareem M; Department of Cell and Tissues, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt., Kamel AA; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Assiut University, Assiut, Egypt., Abou Khalil NS; Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt. nasser82@aun.edu.eg., Hamad D; Department of Physics, Faculty of Science, Assiut University, Assiut, Egypt., Nasr NEH; Technical Manager at Al Esraa Pharmaceutical Optima, Badr City, Cairo, Egypt., Hassan MA; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt., El Faham TH; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Apr 08; Vol. 13 (1), pp. 5790. Date of Electronic Publication: 2023 Apr 08.
DOI: 10.1038/s41598-023-32545-0
Abstrakt: Simvastatin (SV) is a poorly soluble drug; its oral administration is associated with a significant problem: Myopathy. The present study aims to formulate SV microsponges that have the potential to minimize the myotoxicity accompanying the oral administration of the drug. SV microsponges were prepared by exploiting the emulsion solvent evaporation technique. The % entrapment efficiency (%EE) of the drug approached 82.54 ± 1.27%, the mean particle size of SV microsponges ranged from 53.80 ± 6.35 to 86.03 ± 4.79 µm in diameter, and the % cumulative drug release (%CDR) of SV from microsponges was significantly higher than that from free drug dispersion much more, the specific surface area of the optimized microsponges formulation was found to be 16.6 m 2 /g revealed the porosity of prepared microsponges. Histological and glycogen histochemical studies in the skeletal muscles of male albino rats revealed that microsponges were safer than free SV in minimizing myotoxicity. These findings were proven by Gene expression of Mitochondrial fusion and fission (Mfn1) & (Fis1) and (Peroxisome proliferator-activated receptor gamma co-activator 1α) PGC-1α. Finally, our study ascertained that SV microsponges significantly decreased the myotoxicity of SV.
(© 2023. The Author(s).)
Databáze: MEDLINE
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