Remodelling of the intestinal ecosystem during caloric restriction and fasting.

Autor: Ducarmon QR; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Grundler F; Buchinger Wilhelmi Clinic, Wilhelmi-Beck-Straße 27, 88662 Überlingen, Germany., Le Maho Y; University of Strasbourg, CNRS, IPHC UMR, 7178, Strasbourg, France; Centre Scientifique de Monaco, Monaco, Monaco., Wilhelmi de Toledo F; Buchinger Wilhelmi Clinic, Wilhelmi-Beck-Straße 27, 88662 Überlingen, Germany., Zeller G; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. Electronic address: zeller@embl.de., Habold C; University of Strasbourg, CNRS, IPHC UMR, 7178, Strasbourg, France. Electronic address: caroline.habold@iphc.cnrs.fr., Mesnage R; Buchinger Wilhelmi Clinic, Wilhelmi-Beck-Straße 27, 88662 Überlingen, Germany; King's College London, Department of Medical and Molecular Genetics, London, UK. Electronic address: robin.mesnage@buchinger-wilhelmi.com.
Jazyk: angličtina
Zdroj: Trends in microbiology [Trends Microbiol] 2023 Aug; Vol. 31 (8), pp. 832-844. Date of Electronic Publication: 2023 Apr 06.
DOI: 10.1016/j.tim.2023.02.009
Abstrakt: Benefits of fasting and caloric restriction on host metabolic health are well established, but less is known about the effects on the gut microbiome and how this impacts renewal of the intestinal mucosa. What has been repeatedly shown during fasting, however, is that bacteria utilising host-derived substrates proliferate at the expense of those relying on dietary substrates. Considering the increased recognition of the gut microbiome's role in maintaining host (metabolic) health, disentangling host-microbe interactions and establishing their physiological relevance in the context of fasting and caloric restriction is crucial. Such insights could aid in moving away from associations of gut bacterial signatures with metabolic diseases consistently reported in observational studies to potentially establishing causality. Therefore, this review aims to summarise what is currently known or still controversial about the interplay between fasting and caloric restriction, the gut microbiome and intestinal tissue physiology.
Competing Interests: Declaration of interests R.M., F.G. and F.W.T. are employees of the Buchinger Wilhelmi Development and Holding GmbH, Überlingen.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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