The effects of age and biological sex on the association between I-wave recruitment and the response to cTBS: An exploratory study.

Autor: Van Dam JM; Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia; Lifespan Human Neurophysiology Group, School of Biomedicine, University of Adelaide, Adelaide, South Australia 5000, Australia; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia 5000, Australia., Graetz L; Lifespan Human Neurophysiology Group, School of Biomedicine, University of Adelaide, Adelaide, South Australia 5000, Australia; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia 5000, Australia., Pitcher JB; Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia; Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria 3220, Australia., Goldsworthy MR; Lifespan Human Neurophysiology Group, School of Biomedicine, University of Adelaide, Adelaide, South Australia 5000, Australia; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia 5000, Australia. Electronic address: mitchell.goldsworthy@adelaide.edu.au.
Jazyk: angličtina
Zdroj: Brain research [Brain Res] 2023 Jul 01; Vol. 1810, pp. 148359. Date of Electronic Publication: 2023 Apr 06.
DOI: 10.1016/j.brainres.2023.148359
Abstrakt: The neuroplastic response to continuous theta burst stimulation (cTBS) is inherently variable. The measurement of I-wave latencies has been shown to strongly predict the magnitude and direction of the response to cTBS, whereby longer latencies are associated with stronger long-term depression-like responses. However, potential differences in this association relating to age and sex have not been explored. We performed cTBS and measured I-wave recruitment (via MEP latencies) in 66 participants (31 female) ranging in age from 11 to 78 years. The influence of age and sex on the association between I-wave recruitment and the response to cTBS was tested using linear regression models. In contrast to previous studies, there was not a significant association between I-wave latencies and cTBS response at the group level (p = 0.142, R 2  = 0.033). However, there were interactions between I-waves and both age and sex when predicting cTBS response. Subgroup analysis revealed that preferential late I-wave recruitment predicted cTBS response in adolescent females, but not in adolescent or adult males or adult females. These data suggest that the generalisability of I-wave measurement in predicting the response to cTBS may be lower than initially believed. Prediction models should include age and sex, rather than I-wave latencies alone, as our findings suggest that, while each factor alone is not a strong predictor, these factors interact to influence the response to cTBS.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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