Pathological Aspects and Immunohistochemical Evaluation of Troponin C in the Cardiovascular System of Dogs With Pheochromocytoma.

Autor: Argenta FF; Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Slaviero M; Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address: monicaslav.vet@gmail.com., de Mello LS; Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Echenique JVZ; Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Zorzan AA; Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Cony FG; Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Bandinelli MB; Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., de Castro MB; Department of Veterinary Pathology, College of Agronomy and Veterinary Medicine, Universidade de Brasília, Brasília, DF, Brazil., Pavarini SP; Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Driemeier D; Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Sonne L; Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Jazyk: angličtina
Zdroj: Topics in companion animal medicine [Top Companion Anim Med] 2023 Mar-Jun; Vol. 53-54, pp. 100777. Date of Electronic Publication: 2023 Apr 06.
DOI: 10.1016/j.tcam.2023.100777
Abstrakt: Functional pheochromocytomas secrete catecholamines and have been associated with cardiovascular lesions in dogs. This study aimed to describe the postmortem pathological findings in the cardiovascular system of dogs with pheochromocytoma and to evaluate the expression of cardiac troponin C in these dogs using immunohistochemical analysis. Twelve cases were identified, with a mean age of 10.6 years. The heart of all dogs was enlarged and with concentric hypertrophy of the left ventricular myocardium. Histological analysis showed cardiomyocyte necrosis and degeneration in the myocardium, with frequent bands of contraction, fibrosis, inflammation, and thickening of the medium-caliber arteries in the myocardium. There was a marked decrease or absence of immunolabeling in necrotic cardiomyocytes. We conclude that IHC for troponin C can be a useful tool for detecting myocardial necrosis in dogs with pheochromocytomas, including early cases of necrosis with only incipient cardiac changes where overt histologic abnormalities are not immediately apparent in the cardiomyocytes.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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