Descriptive analysis of organophosphate ester metabolites in a pan-Canadian pregnancy cohort.

Autor: Ashley-Martin J; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada. Electronic address: jillian.ashley-martin@hc-sc.gc.ca., MacPherson S; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada. Electronic address: susan.h.macpherson@hc-sc.gc.ca., Zhao Z; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada. Electronic address: zhao.zhao@statcan.gc.ca., Gaudreau É; Centre du Toxicologie du Québec (CTQ), Institut National de Santé Publique du Québec (INSPQ), Québec, QC G1V 5B3, Canada. Electronic address: eric.gaudreau@inspq.qc.ca., Provencher G; Centre du Toxicologie du Québec (CTQ), Institut National de Santé Publique du Québec (INSPQ), Québec, QC G1V 5B3, Canada. Electronic address: gilles.provencher@inspq.qc.ca., Fisher M; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada. Electronic address: mandy.fisher@hc-gc.sc.ca., Borghese MM; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada. Electronic address: michael.borghese@hc-sc.gc.ca., Bouchard MF; Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Laval, Quebec, Canada; Sainte-Justine University Hospital Center, Montreal, Quebec, Canada. Electronic address: maryse.bouchard@inrs.ca., Booij L; Department of Psychiatry, McGill University and Research centre, Douglas Institute, Montreal H4H 1R3, Canada. Electronic address: linda.booij@mcgill.ca., Arbuckle TE; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada. Electronic address: tye.arbuckle@hc-sc.gc.ca.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2023 Jul 20; Vol. 883, pp. 163327. Date of Electronic Publication: 2023 Apr 07.
DOI: 10.1016/j.scitotenv.2023.163327
Abstrakt: Organophosphate esters (OPEs) are widely used in numerous consumer products for their flame retardant and plasticizing properties. Despite potential widespread exposure, biomonitoring data during critical windows of development are scarce and limited to the most widely studied metabolites. We quantified urinary concentrations of multiple OPE metabolites in a vulnerable Canadian population. Using data and biobanked specimens from the Maternal-Infant Research on Environmental Chemicals (MIREC) study (2008-2011), we measured first trimester urinary concentrations of 15 OPE metabolites as well as one flame retardant metabolite and quantified associations with sociodemographic and sample collection characteristics in 1865 pregnant participants. We applied 2 different analytical methods to quantify OPEs, one using UItra-Performance Liquid Chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) and the other using Atmospheric Pressure Gas Chromatography coupled to mass spectrometry (APGC-MS/MS) with sensitive limits of detection (0.008-0.1 μg/L). We modelled associations between sociodemographic and sample collection characteristics and specific gravity-standardized chemical concentrations. Six OPE metabolites were detected in the majority (68.1-97.4 %) of participants. Bis-(2-chloroethyl) hydrogen phosphate had the highest detection rate (97.4 %). Diphenyl phosphate had the highest geometric mean concentration (0.657 μg/L). Metabolites of tricresyl phosphate were detected in few participants. Associations between sociodemographic characteristics varied according to each OPE metabolite. Pre-pregnancy body mass index tended to be positively associated with OPE metabolite concentrations whereas age tended to be inversely associated with OPE concentrations. OPE concentrations were, on average, higher in urine samples collected in the summer than other seasons the winter. We present the largest biomonitoring study of OPE metabolites in pregnant people to date. These findings demonstrate widespread exposure to OPEs and their metabolites and identify subpopulations who may experience heightened exposure.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Crown Copyright © 2023. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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