Quantitative Susceptibility Mapping MRI in Deep-Brain Nuclei in First-Episode Psychosis.

Autor:	García Saborit M; Department of Electrical Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile., Jara A; Department of Statistics, Mathematics Faculty, Pontificia Universidad Catolica de Chile, Santiago, Chile., Muñoz N; Department of Electrical Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile., Milovic C; School of Electrical Engineering, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile., Tepper A; Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile.; Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile., Alliende LM; Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile., Mena C; Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile., Iruretagoyena B; Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile., Ramirez-Mahaluf JP; Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile., Diaz C; Pharmacovigilance, Instituto Psiquiátrico Dr. J. Horwitz Barak, Santiago, Chile., Nachar R; Pharmacovigilance, Instituto Psiquiátrico Dr. J. Horwitz Barak, Santiago, Chile., Castañeda CP; Pharmacovigilance, Instituto Psiquiátrico Dr. J. Horwitz Barak, Santiago, Chile., González A; Early Intervention Program, Instituto Psiquiátrico Dr J. Horwitz Barak, Santiago, Chile.; School of Medicine, Universidad Finis Terrae, Santiago, Chile., Undurraga J; Early Intervention Program, Instituto Psiquiátrico Dr J. Horwitz Barak, Santiago, Chile.; Department of Neurology and Psychiatry, Faculty of Medicine, Clínica Alemana Universidad del Desarrollo, Santiago, Chile., Crossley N; Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile.; Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile., Tejos C; Department of Electrical Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile.
Jazyk:	angličtina
Zdroj:	Schizophrenia bulletin [Schizophr Bull] 2023 Sep 07; Vol. 49 (5), pp. 1355-1363.
DOI:	10.1093/schbul/sbad041
Abstrakt:	Background: Psychosis is related to neurochemical changes in deep-brain nuclei, particularly suggesting dopamine dysfunctions. We used an magnetic resonance imaging-based technique called quantitative susceptibility mapping (QSM) to study these regions in psychosis. QSM quantifies magnetic susceptibility in the brain, which is associated with iron concentrations. Since iron is a cofactor in dopamine pathways and co-localizes with inhibitory neurons, differences in QSM could reflect changes in these processes. Methods: We scanned 83 patients with first-episode psychosis and 64 healthy subjects. We reassessed 22 patients and 21 control subjects after 3 months. Mean susceptibility was measured in 6 deep-brain nuclei. Using linear mixed models, we analyzed the effect of case-control differences, region, age, gender, volume, framewise displacement (FD), treatment duration, dose, laterality, session, and psychotic symptoms on QSM. Results: Patients showed a significant susceptibility reduction in the putamen and globus pallidus externa (GPe). Patients also showed a significant R2* reduction in GPe. Age, gender, FD, session, group, and region are significant predictor variables for QSM. Dose, treatment duration, and volume were not predictor variables of QSM. Conclusions: Reduction in QSM and R2* suggests a decreased iron concentration in the GPe of patients. Susceptibility reduction in putamen cannot be associated with iron changes. Since changes observed in putamen and GPe were not associated with symptoms, dose, and treatment duration, we hypothesize that susceptibility may be a trait marker rather than a state marker, but this must be verified with long-term studies. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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