Short-chain fatty acids are associated with adiposity, energy and glucose homeostasis among different metabolic phenotypes in the Nutritionists' Health Study.

Autor: Solar I; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.; Laboratory of Investigation on Metabolism and Diabetes, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Ribeiro FB; Laboratory of Investigation on Metabolism and Diabetes, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Barbosa MG; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.; Laboratory of Investigation on Metabolism and Diabetes, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., de Oliveira Nascimento Freitas RGB; Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil., Hanada AS; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.; Laboratory of Investigation on Metabolism and Diabetes, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., de Oliveira Ramos C; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.; Nutritional Genomics Laboratory, School of Applied Sciences, University of Campinas, Campinas, São Paulo, Brazil., Sant'Ana MR; Nutritional Genomics Laboratory, School of Applied Sciences, University of Campinas, Campinas, São Paulo, Brazil., Candreva T; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., de Almeida-Pititto B; Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil., Tura A; Metabolic Unit, CNR Institute of Neuroscience, Corso Stati Uniti 4, 35127, Padova, Italy., Cintra DE; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.; Nutritional Genomics Laboratory, School of Applied Sciences, University of Campinas, Campinas, São Paulo, Brazil., Geloneze B; Laboratory of Investigation on Metabolism and Diabetes, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Ferreira SRG; Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil., Vasques ACJ; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil. ana.vasques@fca.unicamp.br.; Laboratory of Investigation on Metabolism and Diabetes, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. ana.vasques@fca.unicamp.br.
Jazyk: angličtina
Zdroj: Endocrine [Endocrine] 2023 Jun; Vol. 80 (3), pp. 529-540. Date of Electronic Publication: 2023 Apr 08.
DOI: 10.1007/s12020-023-03356-0
Abstrakt: Background and Aims: The gut microbiome is associated with obesity, mainly mediated by bacteria-produced short-chain fatty acids (SCFAs). It is unknown how SCFA concentrations are associated with the phenotypes metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy obese/overweight (MHO), and metabolically unhealthy obese/overweight (MUO). We compared plasma and fecal SCFA concentrations among adult women categorized according to the metabolic phenotypes mentioned above and examined associations between SCFA and adiposity and components of energy and glucose homeostasis.
Methods: This was a cross-sectional study involving 111 participants. Body composition was assessed by DEXA. Energy and glycemic homeostasis were assessed by the standard mixed-meal tolerance test coupled with indirect calorimetry. SCFAs were quantified by gas chromatography and mass spectrometry.
Results: Only plasma propionate was increased in the MHNW phenotype compared to the MHO and MUO phenotypes [p < 0.05]. Fecal propionate and butyrate concentrations and plasma propionate concentrations were inversely associated with total and visceral adiposity [p < 0.05]. Fecal and plasma SCFA concentrations were associated with reduced glucose, insulin and HbA1c levels, increased fasting and postprandial GLP-1 levels; and more preserved beta-cell function [p < 0.05]. Fecal and plasma SCFA concentrations were positively correlated with resting energy expenditure and lipid oxidation rate and inversely correlated with the oxidation rate of carbohydrates [p < 0.05].
Conclusion: These findings reinforce the concept that fecal and plasma SCFA concentrations are linked to specific components of energy and glucose homeostasis; and body adiposity. However, it was not possible to discriminate the different metabolic phenotypes of adiposity based on the determination of fecal SCFA concentrations.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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