Therapeutic applications of snake venoms: An invaluable potential of new drug candidates.

Autor: Diniz-Sousa R; Laboratório de Biotecnologia de Proteínas e Compostos Bioativos Aplicados à Saúde (LABIOPROT), Fundação Oswaldo Cruz, FIOCRUZ, Unidade Rondônia, Porto Velho, Rondônia, Brazil; Centro Universitário São Lucas (UniSL), Porto Velho, Rondônia, Brazil., Caldeira CADS; Laboratório de Biotecnologia de Proteínas e Compostos Bioativos Aplicados à Saúde (LABIOPROT), Fundação Oswaldo Cruz, FIOCRUZ, Unidade Rondônia, Porto Velho, Rondônia, Brazil; Serviço Nacional de Aprendizagem Industrial, Departamento Regional de Rondônia (SENAI - DR/RO), Porto Velho, Rondônia, Brazil., Pereira SS; Laboratório de Engenharia de Anticorpos, Fundação Oswaldo Cruz, FIOCRUZ, Unidade Rondônia, Porto Velho, Rondônia, Brazil., Da Silva SL; LAQV/Requimte, University of Porto, Rua do Campo Alegre s/n, Porto, Portugal; Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, Porto, Portugal., Fernandes PA; LAQV/Requimte, University of Porto, Rua do Campo Alegre s/n, Porto, Portugal; Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, Porto, Portugal., Teixeira LMC; LAQV/Requimte, University of Porto, Rua do Campo Alegre s/n, Porto, Portugal; Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, Porto, Portugal., Zuliani JP; Laboratório de Imunologia Celular Aplicada à Saúde, Fundação Oswaldo Cruz, FIOCRUZ, Unidade Rondônia, Porto Velho, Rondônia, Brazil., Soares AM; Laboratório de Biotecnologia de Proteínas e Compostos Bioativos Aplicados à Saúde (LABIOPROT), Fundação Oswaldo Cruz, FIOCRUZ, Unidade Rondônia, Porto Velho, Rondônia, Brazil; Centro Universitário São Lucas (UniSL), Porto Velho, Rondônia, Brazil; Faculdade Católica de Rondônia (FCR), Porto Velho, Rondônia, Brazil; Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental (INCT-EpiAmO), Brazil. Electronic address: andreimar.soares@fiocruz.br.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 May 31; Vol. 238, pp. 124357. Date of Electronic Publication: 2023 Apr 05.
DOI: 10.1016/j.ijbiomac.2023.124357
Abstrakt: Animal venoms and their chemical compounds have aroused both empirical and scientific attention for ages. However, there has been a significant increase in scientific investigations in recent decades, allowing the production of various formulations that are helping in the development of many important tools for biotechnological, diagnostic, or therapeutic use, both in human and animal health, as well as in plants. Venoms are composed of biomolecules and inorganic compounds that may have physiological and pharmacological activities that are not related to their principal actions (prey immobilization, digestion, and defense). Snake venom toxins, mainly enzymatic and non-enzymatic proteins, and peptides have been identified as potential prototypes for new drugs and/or models for the development of pharmacologically active structural domains for the treatment of cancer, cardiovascular diseases, neurodegenerative and autoimmune diseases, pain, and infectious-parasitic diseases. This minireview aims to provide an overview of the biotechnological potential of animal venoms, with a focus on snakes, and to introduce the reader to the fascinating world of Applied Toxinology, where animal biodiversity can be used to develop therapeutic and diagnostic applications for humans.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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