Vaccination coverage and breakthrough infections of COVID-19 during the second wave among staff of selected medical institutions in India.

Autor:	Rahi M; Indian Council of Medical Research, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India., Yadav CP; ICMR- National Institute of Cancer Prevention & Research, Noida, Uttar Pradesh, India.; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India., Ahmad SS; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India., Nitika; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India., Das P; Indian Council of Medical Research, New Delhi, India., Sharma S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India., Baharia RK; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India., Bhattacharya D; Regional Medical Research Centre, Bhubaneshwar, Odisha, India., Deshmukh P; All India Institute of Medical Sciences, Nagpur, Maharshtra, India., Dhatrak A; Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India., Dogra S; Government Medical College, Jammu, Jammu and Kashmir, India., Eapen A; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India., Goel P; Shaheed Hasan Khan Mewati Government Medical College, Mewat, Haryana, India., Faizi N; Aligarh Muslim University, Aligarh, Uttar Pradesh, India., Khan SA; Regional Medical Research Centre, Dibrugarh, Assam, India., Kochar SK; Sardar Patel Medical College, Bikaner, Rajasthan, India., Kochar A; Sardar Patel Medical College, Bikaner, Rajasthan, India., Kumar A; Vector Control Research Centre, Puducherry, India., Mundra A; Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India., Narang R; All India Institute of Medical Sciences, Bibinagar, Telangana, India., Narain K; Regional Medical Research Centre, Dibrugarh, Assam, India., Pandey K; Rajendra Memorial Research Institute of Medical Sciences, Patna, Bihar, India., Pati S; Regional Medical Research Centre, Bhubaneshwar, Odisha, India., Raghav P; All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Ranjha R; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India., Shah S; Aligarh Muslim University, Aligarh, Uttar Pradesh, India., Singh K; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India., Singh PK; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India., Singh RK; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India., Kuttiatt VS; Vector Control Research Centre, Puducherry, India., Soni R; Dayanand Medical College, Ludhiana, Punjab, India., Sreehari U; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India., Malhotra S; All India Institute of Medical Sciences, New Delhi, India., Sharma A; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.; New Delhi and its Field Units (FUs), ICMR- National Institute of Malaria Research, New Delhi, India.; International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
Jazyk:	angličtina
Zdroj:	PLOS global public health [PLOS Glob Public Health] 2023 Apr 07; Vol. 3 (4), pp. e0000946. Date of Electronic Publication: 2023 Apr 07 (Print Publication: 2023).
DOI:	10.1371/journal.pgph.0000946
Abstrakt:	India experienced the second wave of SARS-CoV-2 infection from April 3 to June 10, 2021. During the second wave, Delta variant B.1617.2 emerged as the predominant strain, spiking cases from 12.5 million to 29.3 million (cumulative) by the end of the surge in India. Vaccines against COVID-19 are a potent tool to control and end the pandemic in addition to other control measures. India rolled out its vaccination programme on January 16, 2021, initially with two vaccines that were given emergency authorization-Covaxin (BBV152) and Covishield (ChAdOx1 nCoV- 19). Vaccination was initially started for the elderly (60+) and front-line workers and then gradually opened to different age groups. The second wave hit when vaccination was picking up pace in India. There were instances of vaccinated people (fully and partially) getting infected, and reinfections were also reported. We undertook a survey of staff (front line health care workers and supporting) of 15 medical colleges and research institutes across India to assess the vaccination coverage, incidence of breakthrough infections, and reinfections among them from June 2 to July 10, 2021. A total of 1876 staff participated, and 1484 forms were selected for analysis after removing duplicates and erroneous entries (n = 392). We found that among the respondents at the time of response, 17.6% were unvaccinated, 19.8% were partially vaccinated (received the first dose), and 62.5% were fully vaccinated (received both doses). Incidence of breakthrough infections was 8.7% among the 801 individuals (70/801) tested at least 14 days after the 2nd dose of vaccine. Eight participants reported reinfection in the overall infected group and reinfection incidence rate was 5.1%. Out of (N = 349) infected individuals 243 (69.6%) were unvaccinated and 106 (30.3%) were vaccinated. Our findings reveal the protective effect of vaccination and its role as an essential tool in the struggle against this pandemic. Competing Interests: The authors have declared that no competing interests exist. (Copyright: © 2023 Rahi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze:	MEDLINE
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