Identifying chronic low back pain phenotypic domains and characteristics accounting for individual variation: a systematic review.

Autor:	Hassan S; Institute of Education Research (TIER), University Health Network, Toronto, ON, Canada., Nesovic K; KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada., Babineau J; Institute of Education Research (TIER), University Health Network, Toronto, ON, Canada.; Library and Information Services, University Health Network, Toronto, ON, Canada., Furlan AD; KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada., Kumbhare D; KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada., Carlesso LC; School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
Jazyk:	angličtina
Zdroj:	Pain [Pain] 2023 Oct 01; Vol. 164 (10), pp. 2148-2190. Date of Electronic Publication: 2023 Apr 07.
DOI:	10.1097/j.pain.0000000000002911
Abstrakt:	Abstract: Interpatient variability is frequently observed among individuals with chronic low back pain (cLBP). This review aimed at identifying phenotypic domains and characteristics that account for interpatient variability in cLBP. We searched MEDLINE ALL (through Ovid), Embase Classic and EMBASE (through Ovid), Scopus, and CINAHL Complete (through EBSCOhost) databases. Studies that aimed to identify or predict cLBP different phenotypes were included. We excluded studies that focused on specific treatments. The methodological quality was assessed using an adaptation of the Downs and Black tool. Forty-three studies were included. Although the patient and pain-related characteristics used to identify phenotypes varied considerably across studies, the following were among the most identified phenotypic domains and characteristics that account for interpatient variability in cLBP: pain-related characteristics (including location, severity, qualities, and duration) and pain impact (including disability, sleep, and fatigue), psychological domains (including anxiety and depression), behavioral domains (including coping, somatization, fear avoidance, and catastrophizing), social domains (including employment and social support), and sensory profiling (including pain sensitivity and sensitization). Despite these findings, our review showed that the evidence on pain phenotyping still requires further investigation. The assessment of the methodological quality revealed several limitations. We recommend adopting a standard methodology to enhance the generalizability of the results and the implementation of a comprehensive and feasible assessment framework to facilitate personalized treatments in clinical settings. (Copyright © 2023 International Association for the Study of Pain.)
Databáze:	MEDLINE
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