Comparing the efficacy of sodium hyaluronate eye drops and carboxymethylcellulose eye drops in treating mild to moderate dry eye disease.

Autor: Salim S; Department of Ophthalmology, Kasturba Medical College, Attavar, Mangalore, Karnataka, India., Kamath SJ; Department of Ophthalmology, Kasturba Medical College, Attavar, Mangalore, Karnataka, India., Jeganathan S; Department of Ophthalmology, Kasturba Medical College, Attavar, Mangalore, Karnataka, India., Pai SG; Department of Ophthalmology, ACS Medical College Chennai, Tamil Nadu, India., Mendonca TM; Department of Ophthalmology, Kasturba Medical College, Attavar, Mangalore, Karnataka, India., Kamath AR; Department of Ophthalmology, Kasturba Medical College, Attavar, Mangalore, Karnataka, India.
Jazyk: angličtina
Zdroj: Indian journal of ophthalmology [Indian J Ophthalmol] 2023 Apr; Vol. 71 (4), pp. 1593-1597.
DOI: 10.4103/IJO.IJO_2666_22
Abstrakt: Purpose: Aim of this study was to compare the efficacy of sodium hyaluronate (SH) and carboxymethyl cellulose (CMC) eye drops in treating mild to moderate dry eye disease in terms of relief of symptoms, mean change in tear film breakup time, Schirmer's test, and impression cytology of conjunctiva from baseline.
Methods: An observational study was carried out during a 2-year period in our tertiary referral hospital. The study consisted of 60 patients randomly allotted to two groups to receive SH and CMC eye drops for an 8-week period. Ocular surface disease index, tear film breakup time, and Schirmer's test were performed at baseline visit and 4 and 8 weeks of treatment, and impression cytology of conjunctiva was performed at baseline and 8 weeks.
Results: Significant improvement in patient symptoms, tear film breakup time, and Schirmer's test from baseline was seen in both SH and CMC groups at 8 weeks posttreatment, whereas impression cytology of conjunctiva in both groups did not show significant improvement at 8 weeks of treatment. Data analysis using unpaired t-test showed comparable results.
Conclusion: Both CMC and SH demonstrated equal efficacy in treating mild to moderate dry eye disease.
Competing Interests: None
Databáze: MEDLINE
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