Dental health of patients with X-linked hypophosphatemia: A controlled study.
| Autor: | Larsson A; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.; Public Dental Health Service Stockholm AB, Stockholm, Sweden., Regnstrand T; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden., Skott P; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.; Public Dental Health Service Stockholm AB, Stockholm, Sweden., Mäkitie O; Department of Pediatric Research, Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Clinical Genetics, Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Björnsdottir S; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden., Garming-Legert K; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in oral health [Front Oral Health] 2023 Mar 21; Vol. 4, pp. 1087761. Date of Electronic Publication: 2023 Mar 21 (Print Publication: 2023). |
| DOI: | 10.3389/froh.2023.1087761 |
| Abstrakt: | Objective: The present study compared the dental health of patients with X-linked hypophosphatemia (XLH) with healthy age- and gender-matched controls to increase our knowledge of the impact of XLH on oral health. Materials and Methods: Twenty-two adult patients with XLH in the Stockholm region of Sweden were referred to the Department of Orofacial Medicine at Karolinska Institutet for an extended clinical and radiological examination. Pre-existing radiologic examinations of 44 healthy age- and gender-matched controls were retrieved from the Department of Oral Radiology, at Karolinska Institutet. Results: The 22 patients with XLH (15 females, median age 38 years, range 20-71; 7 males, median age 49 years, range 24-67) had a significantly higher number of root-filled teeth compared to healthy controls ( p = .001). In the XLH group, females had significantly better oral health than males, especially concerning endodontic and cariological status ( p's = .01 and .02, respectively). Periodontal status differed non-significantly between the XLH and control groups. Conclusion: Patients with XLH had a significantly lower oral health status compared to a healthy population especially concerning endodontic conditions. Male patients with XLH had a higher risk of poor oral health compared to female patients with XLH. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Larsson, Regnstrand, Skott, Mäkitie, Björnsdottir and Garming-Legert.) |
| Databáze: | MEDLINE |
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