Enhanced Anti-Rheumatoid Arthritis Activity of Total Alkaloids from Picrasma Quassioides in Collagen-Induced Arthritis Rats by a Targeted Drug Delivery System.
| Autor: | Yuan H; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China., Liu B; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China., Liu F; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China; The Joint Laboratory of Chinese Pharmaceutical University and Taian City Centrol Hospitol, Taian City Central Hospitol, Taian, 271000, China; Pharmacy Department, Taian City Central Hospitol, Taian, 271000, China., Li C; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China., Han L; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China., Huang X; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China., Xue J; The Joint Laboratory of Chinese Pharmaceutical University and Taian City Centrol Hospitol, Taian City Central Hospitol, Taian, 271000, China; Taian City institute of Digestive Disease, Taian City Central Hospitol, Taian, 271000, China., Qu W; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China., Xu J; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China., Liu W; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China., Feng F; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China; Nanjing Medical University, Nanjing, 210009, China. Electronic address: fengfeng@cpu.edu.cn., Wang L; Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: 1019960876@cpu.edu.cn. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of pharmaceutical sciences [J Pharm Sci] 2023 Sep; Vol. 112 (9), pp. 2483-2493. Date of Electronic Publication: 2023 Apr 05. |
| DOI: | 10.1016/j.xphs.2023.03.024 |
| Abstrakt: | New drug delivery systems have rarely been used in the formulation of traditional Chinese medicine, especially those that are crude active Chinese medicinal ingredients. In the present study, hyaluronic acid decorated lipid-polymer hybrid nanoparticles were used to prepare a targeted drug delivery system (TDDS) for total alkaloid extract from Picrasma quassioides (TAPQ) to improve its targeting property and anti-inflammatory activity. Picrasma quassioides, a common-used traditional Chinese medicine (TCM), containing a series of hydrophobic total alkaloids including β-carboline and canthin-6-one alkaloids show great anti-inflammatory activity. However, its high toxicity (IC Competing Interests: Declaration of Competing Interest We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of this manuscript. (Copyright © 2023 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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