Characterization of KPC-2-producing Klebsiella pneumoniae and affected patients of a pediatric hospital in Brazil.

Autor: Barroso MDV; Centro de Investigação de Microrganismos, FAMERP, São José do Rio Preto, São Paulo, Brazil., da Silva CR; Centro de Investigação de Microrganismos, FAMERP, São José do Rio Preto, São Paulo, Brazil., Benfatti LR; Centro de Investigação de Microrganismos, FAMERP, São José do Rio Preto, São Paulo, Brazil., Gozi KS; Centro de Investigação de Microrganismos, FAMERP, São José do Rio Preto, São Paulo, Brazil., de Andrade LK; Centro de Investigação de Microrganismos, FAMERP, São José do Rio Preto, São Paulo, Brazil., Andrade LN; Laboratório de Pesquisa em Resistência e Virulência Bacteriana, FCFRP-USP, Ribeirão Preto, São Paulo, Brazil., Estofolete CF; Centro de Investigação de Microrganismos, FAMERP, São José do Rio Preto, São Paulo, Brazil; Hospital de Base de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil., Nogueira MCL; Centro de Investigação de Microrganismos, FAMERP, São José do Rio Preto, São Paulo, Brazil., Casella T; Centro de Investigação de Microrganismos, FAMERP, São José do Rio Preto, São Paulo, Brazil; Hospital de Base de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil. Electronic address: tiago.casella@famerp.br.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2023 Jun; Vol. 106 (2), pp. 115932. Date of Electronic Publication: 2023 Mar 04.
DOI: 10.1016/j.diagmicrobio.2023.115932
Abstrakt: Carbapenemase-producing Klebsiella pneumoniae (CPKp) infections are important threats to pediatric populations. Thus, a retrospective study was conducted in a Brazilian reference pediatric hospital, and 26 CPKp isolates obtained from 23 patients were characterized. The affected population had important underlying diseases, reflecting previous hospitalization and antibiotic use. Most CPKp isolates were resistant to all antibiotic classes, and bla KPC-2 was the only carbapenemase-encoding gene. bla CTX-M-15 was common among the isolates, and modification or absence of the mgrB gene was the cause of polymyxin B resistance. Ten different sequence types were identified, and clonal complex 258 was prevalent. Alleles wzi50 and wzi64 were the most recurrent ones regarding K-locus type, with a remarkable contribution of the epidemic ST11/KL64 lineage as a colonizer. Our findings show that lineages associated with the pediatric population are similar to those found in adults, reinforcing the need for epidemiological surveillance to effectively implement prevention and control measures.
Competing Interests: Declaration of Competing Interest The authors report no conflicts of interest relevant to this article.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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