Increased detection of Echovirus 6-associated meningitis in patients hospitalized during the COVID-19 pandemic, Israel 2021-2022.

Autor: Fratty IS; Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat-Gan, Israel; The Israel Center for Disease Control, Israel Ministry of Health, Ramat-Gan, Israel., Kriger O; Sheba Medical Center, Pediatric Infectious Disease Unit, Ramat-Gan, Israel., Weiss L; The Israel Center for Disease Control, Israel Ministry of Health, Ramat-Gan, Israel., Vasserman R; The Israel Center for Disease Control, Israel Ministry of Health, Ramat-Gan, Israel., Erster O; The Israel Center for Disease Control, Israel Ministry of Health, Ramat-Gan, Israel., Mendelson E; Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat-Gan, Israel., Sofer D; Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat-Gan, Israel., Weil M; Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat-Gan, Israel. Electronic address: Merav.Weil@sheba.health.gov.il.
Jazyk: angličtina
Zdroj: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2023 May; Vol. 162, pp. 105425. Date of Electronic Publication: 2023 Mar 24.
DOI: 10.1016/j.jcv.2023.105425
Abstrakt: Background: Outbreaks of enteroviral meningitis occur periodically and may lead to hospitalization and severe disease.
Objective: To analyze and describe the meningitis outbreak in patients hospitalized in Israel in 2021-2022, during the COVID-19 pandemic.
Results: In December 2021, before the emergence of the SARS-CoV-2 omicron variant, an off-season increase in enterovirus (EV) infections was observed among patients hospitalized with meningitis. In January 2022, enterovirus cases decreased by 66% in parallel with the peak of the Omicron wave, and then increased rapidly by 78% in March (compared with February) after a decline in Omicron cases. Sequencing of the enterovirus-positive samples showed a dominance of echovirus 6 (E-6) (29%) before and after the Omicron wave. Phylogenetic analysis found that all 29 samples were very similar and all clustered in the E-6 C1 subtype. The main E-6 symptoms observed were fever and headache, along with vomiting and neck stiffness. The median patient age was 25 years, with a broad range (0-60 years).
Conclusion: An upsurge in enterovirus cases was observed after the decline of the SARS-CoV-2 omicron wave. The dominant subtype was E-6, which was present prior to the emergence of the omicron variant, but increased rapidly only after the omicron wave decline. We hypothesize that the omicron wave delayed the rise in E-6-associated meningitis.
Competing Interests: Declaration of Competing Interest None to declare.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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