The impact of COVID-19 in children with Sickle Cell Disease: Results of a multicentric registry.

Autor: Oliveira CM; Departamento de Pediatria, Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Soares VJ; Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Pellegrini Braga JA; Departamento de Pediatria, Universidade Federal de São Paulo, São Paulo, Brazil., Alcantara Bonilha T; IPPMG Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Magalhães I; Hospital da Criança de Brasília José Alencar, Brasília, Brazil., Loggetto SR; Hospital Infantil Sabará, São Paulo, Brazil., Rechenmacher C; Departamento de Pediatria, Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Laboratório de Pediatria Translacional, Serviço de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Daudt LE; Departamento de Pediatria, Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Laboratório de Pediatria Translacional, Serviço de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Unidade de Hematologia e Transplante de Medula Óssea Pediátrica, Serviço de Hematologia Clínica, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Michalowski MB; Departamento de Pediatria, Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Laboratório de Pediatria Translacional, Serviço de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Serviço de Oncologia Pediátrica, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Apr 06; Vol. 18 (4), pp. e0282423. Date of Electronic Publication: 2023 Apr 06 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0282423
Abstrakt: Objective: To analyze the outcomes of children with sickle cell disease (SCD) and COVID-19.
Method: A multicenter prospective study was conducted in five hematological centers from Central and Southeast Brazil, starting in April 2020. The variables recorded include clinical symptoms, diagnostic methods, therapeutic measures, and treatment sites. The clinical repercussions of the infection on the initial treatment and the overall prognosis were also evaluated.
Results: Twenty-five unvaccinated children, aged 4 to 17 years, with SCD and a positive SARS-CoV-2 RT-PCR result participated in this study. Patients were classified as SCD types SS (n = 20, 80%) and SC (n = 5, 20%). Clinical characteristics and evolution were similar in both groups (p>0.05), except for the fetal hemoglobin value which was higher among the SC patients (p = 0.025). The most frequent symptoms were hyperthermia (72%) and cough (40%). Three children were admitted to the intensive care unit, all of whom were overweight/obese (p = 0.078). No deaths were observed.
Conclusions: Although SCD leads to specific complications, the results found in this sample suggest that COVID-19 does not seem to carry an increased mortality risk in pediatric patients with this disease.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Oliveira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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