Two-year multidisciplinary follow-up of COVID-19 patients requiring invasive and noninvasive respiratory support.

Autor:	Tresoldi M; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Zangrillo A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy., Belletti A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ramirez GA; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Milan, Italy., Bozzolo E; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Guzzo F; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Marinosci A; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Fominskiy EV; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., DA Prat V; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Marmiere M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Palumbo D; Department of Radiology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Del Prete L; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy., D'Amico F; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Bellino C; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy., Morando D; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy., Saracino M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ortalda A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Castelli E; Cardiothoracic Department, IRCCS San Raffaele Scientific Institute, Milan, Italy., Rocchi M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Baiardo Redaelli M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Scotti R; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., DI Terlizzi G; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Azzolini ML; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy - azzolini.marialuisa@hsr.it., Guaschino G; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Avitabile E; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Borghi G; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Soddu D; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Dagna L; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Milan, Italy., Landoni G; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy., DE Cobelli F; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Department of Radiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Jazyk:	angličtina
Zdroj:	Minerva medica [Minerva Med] 2023 Dec; Vol. 114 (6), pp. 773-784. Date of Electronic Publication: 2023 Apr 06.
DOI:	10.23736/S0026-4806.22.08397-5
Abstrakt:	Background: COVID-19 patients frequently develop respiratory failure requiring mechanical ventilation. Data on long-term survival of patients who had severe COVID-19 are insufficient. We assessed and compared two-year survival, CT imaging, quality of life, and functional recovery of COVID-19 ARDS patients requiring respiratory support with invasive (IMV) versus noninvasive ventilation (NIV). Methods: Patients with COVID-19 pneumonia admitted up to May 28 th , 2020, who required IMV or NIV, and survived to hospital discharge were enrolled. Patients were contacted two years after discharge to assess vital status, functional, psychological, and cognitive outcomes using validated scales. Patients with persistent respiratory symptoms or high burden of residual lung damage at previous CT scan received a two-year chest CT scan. Results: Out of 61 IMV survivors, 98% were alive at two-year follow-up, and 52 completed the questionnaire. Out of 82 survivors receiving NIV only, 94% were alive at two years, and 47 completed the questionnaire. We found no major differences between invasively and noninvasively ventilated patients, with overall acceptable functional recovery. Among the 99 patients completing the questionnaire, 23 have more than moderate exertional dyspnea. Chest CT scans showed that 4 patients (all received IMV) had fibrotic-like changes. Conclusions: Patients who received mechanical ventilation due to COVID-19 and were discharged from hospital had a 96% survival rate at the two-year follow-up. There was no difference in overall recovery and quality of life between patients who did and did not require IMV, although respiratory morbidity remains high.
Databáze:	MEDLINE
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