Low-dose naltrexone in the treatment of fibromyalgia: A systematic review and narrative synthesis.
| Autor: | Aitcheson N; Nicholas Aitcheson BA, BPhty, MBBS, FAFRM (RACP), FFPMANZCA, Pain and Rehabilitation Specialist, Metro South Pain Rehabilitation Centre, Woolloongabba, Qld; Member, Research Engagement Council, Hopkins Research Centre for Rehabilitation and Resilience, Brisbane, Qld; Adjunct Lecturer, University of Queensland, St Lucia, Qld., Lin Z; Zhen Lin RN, BNurs, Senior Research Assistant, University of Queensland Centre of Clinical Research, Herston, Qld., Tynan K; BPharm, BBioMedSc(Hons), MScMed(PainMgt) MSHPA, Pharmacist, Metro South Pain and Rehabilitation Centre, Woolloongabba, Qld. |
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| Jazyk: | angličtina |
| Zdroj: | Australian journal of general practice [Aust J Gen Pract] 2023 Apr; Vol. 52 (4), pp. 189-195. |
| DOI: | 10.31128/AJGP-09-22-6564 |
| Abstrakt: | Method: A systematic literature search was conducted using the key words 'naltrexone', 'fibromyalgia', 'fibrositis', 'chronic pain' and 'neurogenic inflammation'. Results: Manual exclusion led to the identification of 21 papers, with only five prospective controlled trials of low sample size. Discussion: Low-dose naltrexone may be an effective and safe pharmacotherapy for patients with fibromyalgia. Current evidence lacks power and multisite reproduction. |
| Databáze: | MEDLINE |
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