Non-coding RNAs and Exosomal Non-coding RNAs in Traumatic Brain Injury: the Small Player with Big Actions.

Autor: Mohamadzadeh O; Department of Neurological Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran., Hajinouri M; Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran., Moammer F; Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Tamehri Zadeh SS; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Omid Shafiei G; School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Jafari A; Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.; Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ostadian A; Department of Laboratory Medicine, School of Allied Medical Sciences, Kashan University of Medical Sciences, Kashan, Iran., Talaei Zavareh SA; Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran., Hamblin MR; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa., Yazdi AJ; Neurology Department, Kashan University of Medical Science, Kashan, Iran. Arezoo.jafarian1991@yahoo.com., Sheida A; School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. sheidaamirhossein@gmail.com.; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran. sheidaamirhossein@gmail.com., Mirzaei H; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran. h.mirzaei2002@gmail.com.
Jazyk: angličtina
Zdroj: Molecular neurobiology [Mol Neurobiol] 2023 Jul; Vol. 60 (7), pp. 4064-4083. Date of Electronic Publication: 2023 Apr 05.
DOI: 10.1007/s12035-023-03321-y
Abstrakt: Nowadays, there is an increasing concern regarding traumatic brain injury (TBI) worldwide since substantial morbidity is observed after it, and the long-term consequences that are not yet fully recognized. A number of cellular pathways related to the secondary injury in brain have been identified, including free radical production (owing to mitochondrial dysfunction), excitotoxicity (regulated by excitatory neurotransmitters), apoptosis, and neuroinflammatory responses (as a result of activation of the immune system and central nervous system). In this context, non-coding RNAs (ncRNAs) maintain a fundamental contribution to post-transcriptional regulation. It has been shown that mammalian brains express high levels of ncRNAs that are involved in several brain physiological processes. Furthermore, altered levels of ncRNA expression have been found in those with traumatic as well non-traumatic brain injuries. The current review highlights the primary molecular mechanisms participated in TBI that describes the latest and novel results about changes and role of ncRNAs in TBI in both clinical and experimental research.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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