Evaluation of transorbital sonography measures of optic nerve diameter in the context of global and regional brain volume in multiple sclerosis.

Autor: Antal SI; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Kincses B; Department of Psychiatry, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.; Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany., Veréb D; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Király A; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Tóth E; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Bozsik B; Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Faragó P; Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Szabó N; Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Kocsis K; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Bencsik K; Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Klivényi P; Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Kincses ZT; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary. kincses.zsigmond.tamas@med.u-szeged.hu.; Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary. kincses.zsigmond.tamas@med.u-szeged.hu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Apr 05; Vol. 13 (1), pp. 5578. Date of Electronic Publication: 2023 Apr 05.
DOI: 10.1038/s41598-023-31706-5
Abstrakt: Transorbital sonography (TOS) could be a swift and convenient method to detect the atrophy of the optic nerve, possibly providing a marker that might reflect other quantitative structural markers of multiple sclerosis (MS). Here we evaluate the utility of TOS as a complementary tool for assessing optic nerve atrophy, and investigate how TOS-derived measures correspond to volumetric brain markers in MS. We recruited 25 healthy controls (HC) and 45 patients with relapsing-remitting MS and performed B-mode ultrasonographic examination of the optic nerve. Patients additionally underwent MRI scans to obtain T1-weighted, FLAIR and STIR images. Optic nerve diameters (OND) were compared between HC, MS patients with and without history of optic neuritis (non-ON) using a mixed-effects ANOVA model. The relationship between within-subject-average OND and global and regional brain volumetric measures was investigated using FSL SIENAX, voxel-based morphometry and FSL FIRST. OND was significantly different between HC-MS (HC = 3.2 ± 0.4 mm, MS = 3 ± 0.4 mm; p < 0.019) and we found significant correlation between average OND and normalised whole brain (β = 0.42, p < 0.005), grey matter (β = 0.33, p < 0.035), white matter (β = 0.38, p < 0.012) and ventricular cerebrospinal fluid volume (β = - 0.36, p < 0.021) in the MS group. History of ON had no impact on the association between OND and volumetric data. In conclusion, OND is a promising surrogate marker in MS, that can be simply and reliably measured using TOS, and its derived measures correspond to brain volumetric measures. It should be further explored in larger and longitudinal studies.
(© 2023. The Author(s).)
Databáze: MEDLINE
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