Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats.

Autor: Nagy SA; ELKH-PTE Clinical Neuroscience MR Research Group, Ret Str. 2, 7623, Pecs, Hungary. szilvia.anett.nagy@gmail.com.; Pecs Diagnostic Centre, Rét Street 2, 7623, Pecs, Hungary. szilvia.anett.nagy@gmail.com.; Structural Neurobiology Research Group, Szentágothai Research Centre, University of Pecs, Ifjúság Street 20, 7624, Pecs, Hungary. szilvia.anett.nagy@gmail.com.; Department of Neurology, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary. szilvia.anett.nagy@gmail.com., Ivic I; Pecs Diagnostic Centre, Rét Street 2, 7623, Pecs, Hungary.; Selvita d.o.o., Prilaz Baruna Filipovića 29, 10000, Zagreb, Croatia., Tóth P; ELKH-PTE Clinical Neuroscience MR Research Group, Ret Str. 2, 7623, Pecs, Hungary.; Department of Neurosurgery, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary., Komoly S; Department of Neurology, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary., Kiss T; Szentágothai Research Centre, University of Pecs, Ifjúság Street 20, Pecs, Hungary., Pénzes M; Department of Biochemistry, Eötvös Loránd University, Pázmány Péter Sétány 1/C, 1117, Budapest, Hungary.; Motorpharma Ltd., Szilágyi E. Fasor 27, 1026, Budapest, Hungary., Málnási-Csizmadia A; Motorpharma Ltd., Szilágyi E. Fasor 27, 1026, Budapest, Hungary.; ELKH-ELTE Motor Pharmacology Research Group, Department of Biochemistry, Eötvös Loránd University, Pázmány Péter Sétány 1/C, 1117, Budapest, Hungary., Dóczi T; Pecs Diagnostic Centre, Rét Street 2, 7623, Pecs, Hungary.; Department of Neurosurgery, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary., Perlaki G; ELKH-PTE Clinical Neuroscience MR Research Group, Ret Str. 2, 7623, Pecs, Hungary.; Pecs Diagnostic Centre, Rét Street 2, 7623, Pecs, Hungary.; Department of Neurology, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary.; Department of Neurosurgery, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary., Orsi G; ELKH-PTE Clinical Neuroscience MR Research Group, Ret Str. 2, 7623, Pecs, Hungary.; Pecs Diagnostic Centre, Rét Street 2, 7623, Pecs, Hungary.; Department of Neurology, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary.; Department of Neurosurgery, Medical School, University of Pecs, Rét Street 2, 7623, Pecs, Hungary.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Apr 05; Vol. 13 (1), pp. 5598. Date of Electronic Publication: 2023 Apr 05.
DOI: 10.1038/s41598-023-32679-1
Abstrakt: Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p < 0.0001), while during occlusion there were no significant group differences. At reperfusion, each survival animal showed decreased lesion volume and increased mean ADC of the initial lesion site compared to those during occlusion (p < 10 -6 ), while NS group showed a mixed pattern. At reperfusion, lesion volume and mean ADC of the initial lesion site were significantly associated with 24 h midline-shift and neurological scores. Diffusion MRI performed soon after reperfusion has a great impact in early-phase outcome prediction, and it works better than the measurement during occlusion.
(© 2023. The Author(s).)
Databáze: MEDLINE
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