Texture analysis - A versatile tool for pharmaceutical evaluation of solid oral dosage forms.

Autor: Bogdan C; Department of Dermopharmacy and Cosmetics, Faculty of Pharmacy, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 12 I. Creangă Street, 400010 Cluj-Napoca, Romania., Hales D; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 V. Babes Street, 400012 Cluj-Napoca, Romania. Electronic address: dudas.dana@umfcluj.ro., Cornilă A; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 V. Babes Street, 400012 Cluj-Napoca, Romania., Casian T; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 V. Babes Street, 400012 Cluj-Napoca, Romania., Iovanov R; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 V. Babes Street, 400012 Cluj-Napoca, Romania., Tomuță I; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 V. Babes Street, 400012 Cluj-Napoca, Romania., Iurian S; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 V. Babes Street, 400012 Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2023 May 10; Vol. 638, pp. 122916. Date of Electronic Publication: 2023 Apr 04.
DOI: 10.1016/j.ijpharm.2023.122916
Abstrakt: In the past few decades, texture analysis (TA) has gained importance as a valuable method for the characterization of solid oral dosage forms. As a result, an increasing number of scientific publications describe the textural methods that evaluate the extremely diverse category of solid pharmaceutical products. Within the current work, the use of texture analysis in the characterization of solid oral dosage forms is summarised with a focus on the evaluation of intermediate and finished oral pharmaceutical products. Several texture methods are reviewed regarding the applications in mechanical characterization, and mucoadhesion testing, but also in estimating the disintegration time and in vivo specific features of oral dosage forms. As there are no pharmacopoeial standards for pharmaceutical products tested through texture analysis, and there are important differences between reported results due to different experimental conditions, the choice of testing protocol and parameters is challenging. Thereby, this work aims to guide the research scientists and quality assurance professionals involved in different stages of drug development into the selection of optimal texture methodologies depending on the product characteristics and quality control needs.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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