Health-related quality of life in asthma measured by the World Health Organization brief questionnaire (WHO-BREF) and the effect of concomitant allergic rhinitis-A population-based study.

Autor: Ozoh OB; Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria.; Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria., Aderibigbe SA; Department of Epidemiology and Community Health, University of Ilorin, Ilorin, Nigeria., Ayuk AC; Department of Paediatrics, College of Medicine, University of Nigeria Nsukka-Enugu Campus, Nsukka, Nigeria.; Department of Paediatrics, University of Nigeria Teaching Hospital Ituku/Ozalla, Enugu, Nigeria., Dede SK; Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria., Egbagbe E; Department of Medicine, University of Benin School of Medicine, Benin City, Edo State, Nigeria., Babashani M; Department of Medicine Kano, Aminu Kano Teaching Hospital, Kano, Nigeria.
Jazyk: angličtina
Zdroj: The clinical respiratory journal [Clin Respir J] 2023 Apr 04. Date of Electronic Publication: 2023 Apr 04.
DOI: 10.1111/crj.13608
Abstrakt: Background and Objective: The impact of allergic rhinitis (AR), a common comorbidity in asthma, on global quality of life (QoL) using generic QoL questionnaires has not been extensively evaluated.
Methods: This was a cross-sectional population-based study among adults ≥18 years old. Generic QoL was measured using the World Health Organization (WHO) questionnaire (WHOQOL-BREF), and asthma control was assessed using the Asthma Control Test. Participants were categorized into four groups: Group 1 (No asthma, no AR), Group 2 (Asthma only), Group 3 (AR only) and Group 4 (Concomitant asthma and AR). The student t-test or the ANOVA was used for comparison between groups and based on the level of asthma control. Linear regression was used to assess the association between the level of asthma control and QoL scores, adjusted for age and sex. A p-value of less than 0.05 was considered significant for all associations.
Results: There were 9115 participants; 906 (9.9%) had asthma, and 1998 (21.9%) had AR. The lowest QoL scores were in the environment domain. Mean QoL scores were significantly lower in asthma compared to 'no asthma' and in AR compared to 'no AR'. Either asthma or rhinitis (Group 2 or 3) had significantly lower scores compared to no disease (Group 1) only in the environment domain, but the concomitant disease (Group 4) had lower scores across all categories and domains. Scores were significantly lower for uncontrolled asthma compared to controlled asthma and for 'concomitant asthma and AR' compared to 'asthma only'. Increasing age and uncontrolled asthma predicted worse health-related quality of life (HRQoL) consistently.
Conclusion: Although asthma and AR negatively impact HRQoL independently, concomitant asthma and AR are worse. Uncontrolled asthma underpins poor QoL in asthma because QoL is not impaired in controlled disease. This underscores the need for recognition and treatment of AR in asthma and reinforces the benefits of achieving asthma control as a priority in asthma treatment.
(© 2023 The Authors. The Clinical Respiratory Journal published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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