Sexually Dimorphic Adolescent Trajectories of Prefrontal Endocannabinoid Synaptic Plasticity Equalize in Adulthood, Reflected by Endocannabinoid System Gene Expression.

Autor: Bernabeu A; INMED, INSERM U1249, Marseille, France.; Aix-Marseille University, Marseille, France.; Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University/Indiana University, Bloomington, Indiana, USA., Bara A; INMED, INSERM U1249, Marseille, France.; Aix-Marseille University, Marseille, France.; Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University/Indiana University, Bloomington, Indiana, USA., Murphy Green MN; Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University/Indiana University, Bloomington, Indiana, USA.; The Gill Center for Biomolecular Science and Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA., Manduca A; INMED, INSERM U1249, Marseille, France.; Aix-Marseille University, Marseille, France.; Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University/Indiana University, Bloomington, Indiana, USA., Wager-Miller J; Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University/Indiana University, Bloomington, Indiana, USA.; The Gill Center for Biomolecular Science and Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA., Borsoi M; INMED, INSERM U1249, Marseille, France.; Aix-Marseille University, Marseille, France.; Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University/Indiana University, Bloomington, Indiana, USA., Lassalle O; INMED, INSERM U1249, Marseille, France.; Aix-Marseille University, Marseille, France.; Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University/Indiana University, Bloomington, Indiana, USA., Pelissier-Alicot AL; INMED, INSERM U1249, Marseille, France.; Aix-Marseille University, Marseille, France.; Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University/Indiana University, Bloomington, Indiana, USA.; APHM, CHU Timone Adultes, Service de Médecine Légale, Marseille, France., Chavis P; INMED, INSERM U1249, Marseille, France.; Aix-Marseille University, Marseille, France.; Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University/Indiana University, Bloomington, Indiana, USA., Mackie K; Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University/Indiana University, Bloomington, Indiana, USA.; The Gill Center for Biomolecular Science and Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA., Manzoni OJJ; INMED, INSERM U1249, Marseille, France.; Aix-Marseille University, Marseille, France.; Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University/Indiana University, Bloomington, Indiana, USA.
Jazyk: angličtina
Zdroj: Cannabis and cannabinoid research [Cannabis Cannabinoid Res] 2023 Oct; Vol. 8 (5), pp. 749-767. Date of Electronic Publication: 2023 Apr 04.
DOI: 10.1089/can.2022.0308
Abstrakt: Introduction: How sex influences prefrontal cortexes (PFCs) synaptic development through adolescence remains unclear. Materials and Methods: In this study we describe sex-specific cellular and synaptic trajectories in the rat PFC from adolescence to adulthood. Results: The excitability of PFC layer 5 pyramidal neurons was lower in adult females compared with other developmental stages. The developmental course of endocannabinoid-mediated long-term depression (eCB-LTD) was sexually dimorphic, unlike long-term potentiation or mGluR3-LTD. eCB-LTD was expressed in juvenile females but appeared only at puberty in males. Endovanilloid TRPV1R or eCB receptors were engaged during LTD in a sequential and sexually dimorphic manner. Gene expression of the eCB/vanilloid systems was sequential and sex specific. LTD-incompetent juvenile males had elevated expression levels of the CB1R-interacting inhibitory protein cannabinoid receptor interacting protein 1a and of the 2-arachidonoylglycerol-degrading enzyme ABHD6. Pharmacological inhibition of ABHD6 or MAGL enabled LTD in young males, whereas inhibition of anandamide degradation was ineffective. Conclusions: These results reveal sex differences in the maturational trajectories of the rat PFC.
Databáze: MEDLINE
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