Zooanthroponotic transmission of SARS-CoV-2 and host-specific viral mutations revealed by genome-wide phylogenetic analysis.

Autor:	Naderi S; Department of Microbiology & Immunology, McGill University, Montreal, Canada., Chen PE; Department of Microbiology & Immunology, McGill University, Montreal, Canada.; Département de sciences biologiques, Université de Montréal, Montreal, Canada., Murall CL; Department of Microbiology & Immunology, McGill University, Montreal, Canada.; Public Health Agency of Canada, Winnipeg, Canada., Poujol R; Research Centre, Montreal Heart Institute, Montreal, Canada., Kraemer S; Department of Microbiology & Immunology, McGill University, Montreal, Canada., Pickering BS; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Canada.; Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, United States.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada., Sagan SM; Department of Microbiology & Immunology, McGill University, Montreal, Canada.; Department of Biochemistry, McGill University, Montreal, Canada., Shapiro BJ; Department of Microbiology & Immunology, McGill University, Montreal, Canada.; McGill Genome Centre, Montreal, Canada.; McGill Centre for Microbiome Research, Montreal, Canada.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2023 Apr 04; Vol. 12. Date of Electronic Publication: 2023 Apr 04.
DOI:	10.7554/eLife.83685
Abstrakt:	Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a generalist virus, infecting and evolving in numerous mammals, including captive and companion animals, free-ranging wildlife, and humans. Transmission among non-human species poses a risk for the establishment of SARS-CoV-2 reservoirs, makes eradication difficult, and provides the virus with opportunities for new evolutionary trajectories, including the selection of adaptive mutations and the emergence of new variant lineages. Here, we use publicly available viral genome sequences and phylogenetic analysis to systematically investigate the transmission of SARS-CoV-2 between human and non-human species and to identify mutations associated with each species. We found the highest frequency of animal-to-human transmission from mink, compared with lower transmission from other sampled species (cat, dog, and deer). Although inferred transmission events could be limited by sampling biases, our results provide a useful baseline for further studies. Using genome-wide association studies, no single nucleotide variants (SNVs) were significantly associated with cats and dogs, potentially due to small sample sizes. However, we identified three SNVs statistically associated with mink and 26 with deer. Of these SNVs, ~⅔ were plausibly introduced into these animal species from local human populations, while the remaining ~⅓ were more likely derived in animal populations and are thus top candidates for experimental studies of species-specific adaptation. Together, our results highlight the importance of studying animal-associated SARS-CoV-2 mutations to assess their potential impact on human and animal health. Competing Interests: SN, PC, CM, RP, SK, BP, SS, BS No competing interests declared (© 2023, Naderi et al.)
Databáze:	MEDLINE
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