The effects of simvastatin and fenofibrate on malondialdehyde and reduced glutathione concentrations in the plasma, liver, and brain of normolipidaemic and hyperlipidaemic rats.

Autor:	Vukšić A; Clinical Hospital Centre Zagreb, Department of Neurology, Zagreb, Croatia., Rašić D; Institute for Medical Research and Occupational Health, Unit of Toxicology, Zagreb, Croatia., Žunec S; Institute for Medical Research and Occupational Health, Unit of Toxicology, Zagreb, Croatia., Božina T; University of Zagreb School of Medicine, Department of Medical Chemistry, Biochemistry, and Clinical Chemistry, Zagreb, Croatia., Konjevoda P; Ruđer Bošković Institute, NMR Centre, Zagreb, Croatia., Lovrić J; University of Zagreb School of Medicine, Department of Medical Chemistry, Biochemistry, and Clinical Chemistry, Zagreb, Croatia., Bilušić M; Polyclinic Bonifarm, Department of Clinical Pharmacology and Toxicology, Zagreb, Croatia., Bradamante V; University of Zagreb School of Medicine, Department of Pharmacology, Zagreb, Croatia.
Jazyk:	angličtina
Zdroj:	Arhiv za higijenu rada i toksikologiju [Arh Hig Rada Toksikol] 2023 Apr 04; Vol. 74 (1), pp. 34-41. Date of Electronic Publication: 2023 Apr 04 (Print Publication: 2023).
DOI:	10.2478/aiht-2023-74-3697
Abstrakt:	The objective of study was to investigate the effects of different doses of simvastatin and fenofibrate on malondialdehyde (MDA) and reduced glutathione (GSH) in the plasma, liver, and brain tissue of male normolipidaemic and hyperlipidaemic rats. Normolipidaemic (Wistar) rats were receiving 10 or 50 mg/kg a day of simvastatin or 30 or 50 mg/kg a day of fenofibrate. Hyperlipidaemic (Zucker) rats were receiving 50 mg/kg/day of simvastatin or 30 mg/kg/day of fenofibrate. Control normolipidaemic and hyperlipidaemic rats were receiving saline. Simvastatin, fenofibrate, and saline were administered by gavage for three weeks. In normolipidaemic rats simvastatin and fenofibrate showed similar and dose-independent effects on plasma and brain MDA and GSH concentrations. Generally, plasma and brain MDA decreased, while brain GSH concentration increased. In hyperlipidaemic rats simvastatin did not affect plasma and brain MDA and GSH concentrations but significantly decreased liver GSH. Fenofibrate decreased plasma and liver MDA but increased brain MDA. In both rat strains fenofibrate significantly decreased liver GSH concentrations, most likely because fenofibrate metabolites bind to GSH. Our findings suggest that simvastatin acts as an antioxidant only in normolipidaemic rats, whereas fenofibrate acts as an antioxidant in both rat strains. (© 2023 Antonija Vukšić et al., published by Sciendo.)
Databáze:	MEDLINE
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