Component Costs of CAR-T Therapy in Addition to Treatment Acquisition Costs in Patients with Multiple Myeloma.

Autor: Jagannath S; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Joseph N; Janssen Scientific Affairs, LLC, Horsham, PA, USA., Crivera C; Janssen Scientific Affairs, LLC, Horsham, PA, USA., Kharat A; Janssen Scientific Affairs, LLC, Horsham, PA, USA. AKharat2@its.jnj.com., Jackson CC; Janssen R&D, Raritan, NJ, USA., Valluri S; Janssen Global Services, LLC, Raritan, NJ, USA., Cost P; Janssen Global Services, LLC, Raritan, NJ, USA., Phelps H; Janssen Global Services, LLC, Raritan, NJ, USA., Slowik R; Janssen Global Services, LLC, Raritan, NJ, USA., Klein T; Medical Decision Modeling Inc., Indianapolis, IN, USA., Smolen L; Medical Decision Modeling Inc., Indianapolis, IN, USA., Yu X; Medical Decision Modeling Inc., Indianapolis, IN, USA., Cohen AD; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Jazyk: angličtina
Zdroj: Oncology and therapy [Oncol Ther] 2023 Jun; Vol. 11 (2), pp. 263-275. Date of Electronic Publication: 2023 Apr 04.
DOI: 10.1007/s40487-023-00228-5
Abstrakt: Introduction: Ciltacabtagene autoleucel (cilta-cel), is a B-cell maturation antigen-directed, genetically modified autologous chimeric antigen receptor T-cell (CAR-T) immunotherapy. It is indicated for treatment for adult patients with relapsed or refractory multiple myeloma (RRMM) after four or more prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. The objective of this study was to estimate the per-patient US commercial healthcare costs related to cilta-cel (CARVYKTI ® ) CAR-T therapy (i.e., costs separate from cilta-cel therapy acquisition) for patients with RRMM.
Methods: US prescribing information for cilta-cel, publicly available data, and published literature were used with clinician input to identify the cost components and unit costs associated with administration of cilta-cel. Cost components included apheresis, bridging therapy, conditioning therapy, administration, and postinfusion monitoring for 1 year of follow-up. Adverse event (AE) management costs for all grades of cytokine release syndrome and neurologic toxicities, and additional AEs grade ≥ 3 occurring in > 5% of patients were included in the analysis.
Results: The estimated per-patient average costs of cilta-cel CAR-T therapy administered exclusively in an inpatient setting, excluding cilta-cel therapy acquisition costs, totaled US$160,933 over a 12 month period. Costs assuming different proportions of inpatient/outpatient administration (85%/15% and 70%/30%) were US$158,095 and US$155,257, respectively.
Conclusion: Cost estimates from this analysis, which disaggregates CAR-T therapy costs, provide a comprehensive view of the cost components of CAR-T therapy that can help healthcare decision-makers make informed choices regarding the use of cilta-cel. Real-world costs may differ with improved AE prevention and mitigation strategies.
(© 2023. The Author(s).)
Databáze: MEDLINE
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