An assembly of TROP2-mediated signaling events.

Autor: Upadhyay SS; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to Be University), Mangalore, 575018, India., Devasahayam Arokia Balaya R; Centre for Integrative Omics Data Science, Yenepoya (Deemed to Be University), Mangalore, 575018, India. rexprem@yenepoya.edu.in., Parate SS; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to Be University), Mangalore, 575018, India., Dagamajalu S; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to Be University), Mangalore, 575018, India., Keshava Prasad TS; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to Be University), Mangalore, 575018, India., Shetty R; Department of Surgical Oncology, Yenepoya Medical College Hospital, Yenepoya (Deemed to Be University), Mangalore, 575018, India. shettyrohan@rediffmail.com., Raju R; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to Be University), Mangalore, 575018, India. rajeshraju@yenepoya.edu.in.; Centre for Integrative Omics Data Science, Yenepoya (Deemed to Be University), Mangalore, 575018, India. rajeshraju@yenepoya.edu.in.
Jazyk: angličtina
Zdroj: Journal of cell communication and signaling [J Cell Commun Signal] 2023 Sep; Vol. 17 (3), pp. 1105-1111. Date of Electronic Publication: 2023 Apr 04.
DOI: 10.1007/s12079-023-00742-1
Abstrakt: Trophoblast cell surface antigen 2 (TROP2) is a calcium-transducing transmembrane protein mainly involved in embryo development. The aberrant expression of TROP2 is observed in numerous cancers, including triple-negative breast cancer, gastric, colorectal, pancreatic, squamous cell carcinoma of the oral cavity, and prostate cancers. The main signaling pathways mediated by TROP2 are calcium signaling, PI3K/AKT, JAK/STAT, MAPKs, and β-catenin signaling. However, collective information about the TROP2-mediated signaling pathway is not available for visualization or analysis. In this study, we constructed a TROP2 signaling map with respect to its role in different cancers. The data curation was done manually by following the NetPath annotation criteria. The described map consists of different molecular events, including 8 activation/inhibition, 16 enzyme catalysis, 19 gene regulations, 12 molecular associations, 39 induced-protein expressions, and 2 protein translocation. The data of the TROP2 pathway map is made freely accessible through the WikiPathways Database ( https://www.wikipathways.org/index.php/Pathway:WP5300 ). Development of TROP2 signaling pathway map.
(© 2023. The International CCN Society.)
Databáze: MEDLINE
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