Dynamic evolution of brain structural patterns in liver transplantation recipients: a longitudinal study based on 3D convolutional neuronal network model.

Autor: Cheng Y; Department of Radiology, Tianjin First Central Hospital, Tianjin, China.; College of Intelligence and Computing, Tianjin Key Laboratory of Cognitive Computing and Application, Tianjin University, Tianjin, China., Zhang XD; Department of Radiology, Tianjin First Central Hospital, Tianjin, China.; College of Intelligence and Computing, Tianjin Key Laboratory of Cognitive Computing and Application, Tianjin University, Tianjin, China., Chen C; College of Intelligence and Computing, Tianjin Key Laboratory of Cognitive Computing and Application, Tianjin University, Tianjin, China.; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China., He LF; College of Intelligence and Computing, Tianjin Key Laboratory of Cognitive Computing and Application, Tianjin University, Tianjin, China.; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China., Li FF; Department of Radiology, Tianjin First Central Hospital, Tianjin, China., Lu ZN; Department of Radiology, Tianjin First Central Hospital, Tianjin, China., Man WQ; Department of Radiology, Tianjin First Central Hospital, Tianjin, China., Zhao YJ; Department of Radiology, Tianjin First Central Hospital, Tianjin, China., Chang ZX; School of Medicine, Nankai University, Tianjin, China., Wu Y; School of Statistics and Data Science, Key Laboratory for Medical Data Analysis and Statistical Research of Tianjin, Nankai University, Tianjin, China., Shen W; Department of Radiology, Tianjin First Central Hospital, Tianjin, China., Fan LZ; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China., Xu JH; College of Intelligence and Computing, Tianjin Key Laboratory of Cognitive Computing and Application, Tianjin University, Tianjin, China. jhxu@tju.edu.cn.
Jazyk: angličtina
Zdroj: European radiology [Eur Radiol] 2023 Sep; Vol. 33 (9), pp. 6134-6144. Date of Electronic Publication: 2023 Apr 04.
DOI: 10.1007/s00330-023-09604-1
Abstrakt: Objectives: To evaluate the dynamic evolution process of overall brain health in liver transplantation (LT) recipients, we employed a deep learning-based neuroanatomic biomarker to measure longitudinal changes of brain structural patterns before and 1, 3, and 6 months after surgery.
Methods: Because of the ability to capture patterns across all voxels from a brain scan, the brain age prediction method was adopted. We constructed a 3D-CNN model through T1-weighted MRI of 3609 healthy individuals from 8 public datasets and further applied it to a local dataset of 60 LT recipients and 134 controls. The predicted age difference (PAD) was calculated to estimate brain changes before and after LT, and the network occlusion sensitivity analysis was used to determine the importance of each network in age prediction.
Results: The PAD of patients with cirrhosis increased markedly at baseline (+ 5.74 years) and continued to increase within one month after LT (+ 9.18 years). After that, the brain age began to decrease gradually, but it was still higher than the chronological age. The PAD values of the OHE subgroup were higher than those of the no-OHE, and the discrepancy was more obvious at 1-month post-LT. High-level cognition-related networks were more important in predicting the brain age of patients with cirrhosis at baseline, while the importance of primary sensory networks increased temporarily within 6-month post-LT.
Conclusions: The brain structural patterns of LT recipients showed inverted U-shaped dynamic change in the early stage after transplantation, and the change in primary sensory networks may be the main contributor.
Key Points: • The recipients' brain structural pattern showed an inverted U-shaped dynamic change after LT. • The patients' brain aging aggravated within 1 month after surgery, and the subset of patients with a history of OHE was particularly affected. • The change of primary sensory networks is the main contributor to the change in brain structural patterns.
(© 2023. The Author(s), under exclusive licence to European Society of Radiology.)
Databáze: MEDLINE