Surgical polarimetric endoscopy for the detection of laryngeal cancer.

Autor: Qi J; Research Center for Humanoid Sensing, Zhejiang Lab, Hangzhou, China. ji.qi@zhejianglab.edu.cn.; Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, UK. ji.qi@zhejianglab.edu.cn.; Department of Computer Science, University College London, London, UK. ji.qi@zhejianglab.edu.cn.; Centre For Medical Image Computing, University College London, London, UK. ji.qi@zhejianglab.edu.cn.; Hamlyn Centre for Robotic Surgery, Imperial College London, London, UK. ji.qi@zhejianglab.edu.cn.; Department of Surgery and Cancer, Imperial College London, London, UK. ji.qi@zhejianglab.edu.cn., Tatla T; Hamlyn Centre for Robotic Surgery, Imperial College London, London, UK.; Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK., Nissanka-Jayasuriya E; William Harvey Hospital, East Kent Hospitals University NHS Foundation Trust, London, UK., Yuan AY; Department of Electrical and Electronic Engineering, Imperial College London, London, UK., Stoyanov D; Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, UK. danail.stoyanov@ucl.ac.uk.; Department of Computer Science, University College London, London, UK. danail.stoyanov@ucl.ac.uk.; Centre For Medical Image Computing, University College London, London, UK. danail.stoyanov@ucl.ac.uk., Elson DS; Hamlyn Centre for Robotic Surgery, Imperial College London, London, UK. daniel.elson@imperial.ac.uk.; Department of Surgery and Cancer, Imperial College London, London, UK. daniel.elson@imperial.ac.uk.
Jazyk: angličtina
Zdroj: Nature biomedical engineering [Nat Biomed Eng] 2023 Aug; Vol. 7 (8), pp. 971-985. Date of Electronic Publication: 2023 Apr 03.
DOI: 10.1038/s41551-023-01018-0
Abstrakt: The standard-of-care for the detection of laryngeal pathologies involves distinguishing suspicious lesions from surrounding healthy tissue via contrasts in colour and texture captured by white-light endoscopy. However, the technique is insufficiently sensitive and thus leads to unsatisfactory rates of false negatives. Here we show that laryngeal lesions can be better detected in real time by taking advantage of differences in the light-polarization properties of cancer and healthy tissues. By measuring differences in polarized-light retardance and depolarization, the technique, which we named 'surgical polarimetric endoscopy' (SPE), generates about one-order-of-magnitude greater contrast than white-light endoscopy, and hence allows for the better discrimination of cancerous lesions, as we show with patients diagnosed with squamous cell carcinoma. Polarimetric imaging of excised and stained slices of laryngeal tissue indicated that changes in the retardance of polarized light can be largely attributed to architectural features of the tissue. We also assessed SPE to aid routine transoral laser surgery for the removal of a cancerous lesion, indicating that SPE can complement white-light endoscopy for the detection of laryngeal cancer.
(© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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