Acetabular dysplasia and the risk of developing hip osteoarthritis at 2,5,8, and 10 years follow-up in a prospective nationwide cohort study (CHECK).

Autor: Riedstra NS; Department of Orthopaedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Van Diemenstraat 184, Rotterdam, The Hague 2518VH, the Netherlands. Electronic address: n.riedstra@erasmusmc.nl., Vinge R; Department of Clinical Sciences, Lund University, Lund, Sweden., Herfkens J; Department of Orthopaedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Van Diemenstraat 184, Rotterdam, The Hague 2518VH, the Netherlands., Eygendaal D; Department of Orthopaedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Van Diemenstraat 184, Rotterdam, The Hague 2518VH, the Netherlands., Bierma-Zeinstra SMA; Department of Orthopaedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Van Diemenstraat 184, Rotterdam, The Hague 2518VH, the Netherlands; Department of General Practice, Erasmus MC Medical Center Rotterdam, Rotterdam, the Netherlands., Runhaar J; Department of General Practice, Erasmus MC Medical Center Rotterdam, Rotterdam, the Netherlands., van Buuren MMA; Department of Orthopaedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Van Diemenstraat 184, Rotterdam, The Hague 2518VH, the Netherlands., Agricola R; Department of Orthopaedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Van Diemenstraat 184, Rotterdam, The Hague 2518VH, the Netherlands.
Jazyk: angličtina
Zdroj: Seminars in arthritis and rheumatism [Semin Arthritis Rheum] 2023 Jun; Vol. 60, pp. 152194. Date of Electronic Publication: 2023 Mar 30.
DOI: 10.1016/j.semarthrit.2023.152194
Abstrakt: Objective: To assess the relationship between acetabular dysplasia (AD) and the risk of incident and end-stage radiographic hip osteoarthritis (RHOA) over 2,5,8 and 10 years.
Design: Individuals (n = 1002) aged between 45 and 65 from the prospective Cohort Hip and Cohort Knee (CHECK) were studied. Anteroposterior pelvic radiographs were obtained at baseline and 2,5,8, and 10-years follow-up. False profile radiographs were obtained at baseline. AD was defined as a lateral center edge angle, an anterior center edge angle, or both <25° at baseline. The risk of developing RHOA was determined at each follow-up moment. Incident RHOA was defined by Kellgren & Lawrence (KL) grade ≥2 or total hip replacement (THR), end-stage RHOA by a KL grade ≥3 or THR. Associations were expressed in odds ratios (OR) using logistic regression with generalized estimating equations.
Results: AD was associated with the development of incident RHOA at 2 years follow-up (OR 2.46, 95% CI 1.00-6.04), 5 years follow-up (OR 2.28, 95% CI 1.20-4.31), and 8 years follow-up (OR 1.86, 95%CI 1.22-2.83). AD was only associated with end-stage RHOA at 5 years follow-up (OR 3.75, 95% CI 1.02-13.77). No statistically significant associations were observed between AD and RHOA at 10-years follow-up.
Conclusion: Baseline AD in individuals between 45 and 65 years is associated with an increased risk of developing RHOA within 2- and 5 years. However, this association seems to weaken after 8 years and disappears after 10 years.
Competing Interests: Declaration of Competing Interest No conflict of interest to disclose.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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