Use of honokiol in lung cancer therapy: a mini review of its pharmacological mechanism.

Autor: Wang J; Department of Biology Science and Technology, Baotou Teacher's College, Baotou 014030, China., Mu HJ; Department of Drug Clinical Trials, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China., Sun YL; Department of Hepatobiliary Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China., Yuan B; Department of Pharmacy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China., Wang Y; Department of Pharmacy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China.
Jazyk: angličtina
Zdroj: Journal of Asian natural products research [J Asian Nat Prod Res] 2023 Nov; Vol. 25 (11), pp. 1029-1037. Date of Electronic Publication: 2023 Apr 03.
DOI: 10.1080/10286020.2023.2193695
Abstrakt: Honokiol (3',5-di-(2-propenyl)-1,1'-biphenyl-2,2'-diol) is a biologically active natural product derived from Magnolia and has been shown to have excellent biological activities. This paper discusses research progress on the use of honokiol in the treatment of lung cancer, as studies have confirmed that honokiol can exert anti-lung-cancer effects through multiple pathways and multiple signaling pathways, such as inhibiting angiogenesis, affecting mitochondrial function and apoptosis, regulating of autophagy and epithelial-mesenchymal transition (EMT). In addition, honokiol combined with other chemotherapy drugs is also a way in which it can be applied.
Databáze: MEDLINE
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