Anti-SAE autoantibody in dermatomyositis: original comparative study and review of the literature.

Autor:	Demortier J; Department of Dermatology, Henri Mondor University Hospital, AP-HP, Créteil, France., Vautier M; Department of Internal Medicine and Clinical Immunology, Pitié-Salpêtrière University Hospital, Sorbonne Université, AP-HP, Paris, France., Chosidow O; Department of Dermatology, Henri Mondor University Hospital, Université Paris-Est Créteil, AP-HP, Créteil, France., Gallay L; Department of Internal Medicine and Clinical Immunology, Edouard Herriot University Hospital, Claude Bernard University Lyon1, Lyon, France., Bessis D; Department of Dermatology, University Hospital Center of Montpellier, Montpellier, France., Berezne A; Department of Internal Medicine, CHR Annecy-Genevois, Annecy, France., Cordel N; Department of Dermatology and Clinical Immunology, Guadeloupe University Hospital, Pointe-à-Pitre, Guadeloupe and Normandie University, UNIROUEN, IRIB, Inserm, U1234, Rouen, France., Schmidt J; Department of Internal Medicine and Clinical Immunology, Amiens-Picardie Nord University Hospital, Amiens, France., Smail A; Department of Internal Medicine and Clinical Immunology, Amiens-Picardie Nord University Hospital, Amiens, France., Duffau P; Department of Internal Medicine, Saint André, Bordeaux University Hospital, Bordeaux, France., Jachiet M; Department of Dermatology, Saint-Louis Hospital, AP-HP, Paris, France., Begon E; Department of Dermatology, René Dubos Hospital, Pontoise, France., Gottlieb J; Department of Internal Medicine and Clinical Immunology, Bicêtre Hospital, Université Paris-Sud, AP-HP, Le Kremlin-Bicêtre Cedex, France., Chasset F; Department of Dermatology, Tenon Hospital, Sorbonne Université, AP-HP, Paris, France., Graveleau J; Department of Internal Medicine, CH de St Nazaire, St Nazaire, France., Marque M; Department of Dermatology, Caremeau Hospital, Nîmes University Hospital, Nîmes, France., Cesbron E; Department of Dermatology, Le Mans Hospital Center, Le Mans, France., Forestier A; Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Mutualiste, Grenoble, France., Josse S; Department of Internal Medicine and Clinical Immunology, Dieppe Hospital, Dieppe, France., Kluger N; Department of Dermatology, Helsinki University Hospital, Helsinki, Finland., Beauchêne C; Department of Dermatology, Angers University Hospital, Angers, France., Le Corre Y; Department of Dermatology, Angers University Hospital, Angers, France., Pagis V; Department of Internal Medicine and Clinical Immunology, Beaujon Hospital, AP-HP, Paris, France., Rigolet A; Department of Internal Medicine and Clinical Immunology, Pitié-Salpêtrière University Hospital, Sorbonne Université, AP-HP, Paris, France., Guillaume-Jugnot P; Department of Internal Medicine and Clinical Immunology, Pitié-Salpêtrière University Hospital, Sorbonne Université, AP-HP, Paris, France., Authier FJ; Department of Pathology, Henri-Mondor University Hospital, Institut Mondor de Recherche Biomédicale, INSERM, Centre de Reference pour les Maladies Neuromusculaires of Nord-Est-Île de France, Université Paris-Est Créteil, AP-HP, Créteil, France., Guilain N; Department of Pathology, Amiens Picardie University Hospital, Amiens, France., Streichenberger N; Neuropathology Department, Hospices Civils Lyon, Claude Bernard University Lyon1, Lyon, France., Leonard-Louis S; Neuropathology Department, Pitié-Salpêtrière University Hospital, Sorbonne Université, AP-HP, Paris, France., Boussouar S; ICT Cardiothoracic Imaging Unit, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, Paris, France., Landon-Cardinal O; Division of Rheumatology, Centre Hospitalier de l'Université de Montréal (CHUM), CHUM Research Center, Department of Medicine, Université de Montréal, Montréal, Québec, Canada., Benveniste O; Department of Internal Medicine and Clinical Immunology, Pitié-Salpêtrière University Hospital, Sorbonne Université, AP-HP, Paris, France., Allenbach Y; Department of Internal Medicine and Clinical Immunology, Pitié-Salpêtrière University Hospital, Sorbonne Université, AP-HP, Paris, France.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2023 Dec 01; Vol. 62 (12), pp. 3932-3939.
DOI:	10.1093/rheumatology/kead154
Abstrakt:	Objective: Among specific autoantibodies in DM, the anti-small ubiquitin-like modifier activating enzyme (SAE) antibody is rare. We aim to describe the clinical characteristics, cancer prevalence, and muscle pathology of anti-SAE-positive DM. Methods: Patients with a diagnosis of DM and sera positive for the anti-SAE antibody were recruited from 19 centres in this retrospective observational study. The available muscular biopsies were reviewed. We conducted a comparison with anti-SAE-negative DM and a review of the literature. Results: Of the patients in the study (n = 49), 84% were women. Skin involvement was typical in 96% of patients, with 10% having calcinosis, 18% ulceration and 12% necrosis; 35% presented with a widespread skin rash. Muscular disease affected 84% of patients, with mild weakness [Medical Research Council (MRC) scale 4 (3, 5)], although 39% of patients had dysphagia. Muscular biopsies showed typical DM lesions. Interstitial lung disease was found in 21% of patients, mainly with organizing pneumonia pattern, and 26% of patients showed dyspnoea. Cancer-associated myositis was diagnosed in 16% of patients and was responsible for the majority of deaths, its prevalence being five times that of the general population. IVIG therapy was administered to 51% of the patients during the course of the disease. Comparison with anti-SAE-negative DM (n = 85) showed less and milder muscle weakness (P = 0.02 and P = 0.006, respectively), lower creatinine kinase levels (P < 0.0001) and less dyspnoea (P = 0.003). Conclusion: Anti-SAE positive DM is a rare subgroup associated with typical skin features but a potentially diffuse rash, a mild myopathy. Interstitial lung disease defines an organizing pneumonia pattern. Cancer associated DM prevalence is five times that of the general population. Trial Registration: ClinicalTrials.gov, http://clinicaltrials.gov, NCT04637672. (© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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