Early-life immune expression profiles predict later-life health and fitness in a wild rodent.

Autor: Wanelik KM; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Begon M; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Bradley JE; School of Life Sciences, University of Nottingham, Nottingham, UK., Friberg IM; School of Science, Engineering and Environment, University of Salford, Salford, UK., Taylor CH; School of Life Sciences, University of Nottingham, Nottingham, UK., Jackson JA; School of Science, Engineering and Environment, University of Salford, Salford, UK., Paterson S; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Jazyk: angličtina
Zdroj: Molecular ecology [Mol Ecol] 2023 Jul; Vol. 32 (13), pp. 3471-3482. Date of Electronic Publication: 2023 Apr 17.
DOI: 10.1111/mec.16950
Abstrakt: Individuals differ in the nature of the immune responses they produce, affecting disease susceptibility and ultimately health and fitness. These differences have been hypothesized to have an origin in events experienced early in life that then affect trajectories of immune development and responsiveness. Here, we investigate how early-life immune expression profiles influence life history outcomes in a natural population of field voles, Microtus agrestis, in which we are able to monitor variation between and within individuals through time by repeat sampling of individually marked animals. We analysed the co-expression of 20 immune genes in early life to create a correlation network consisting of three main clusters, one of which (containing Gata3, Il10 and Il17) was associated with later-life reproductive success and susceptibility to chronic bacterial (Bartonella) infection. More detailed analyses supported associations between early-life expression of Il17 and reproductive success later in life, and of Il10 expression early in life and later infection with Bartonella. We also found significant association between an Il17 genotype and the early-life expression of Il10. Our results demonstrate that immune expression profiles can be manifested during early life with effects that persist through adulthood and that shape the variability among individuals in susceptibility to infection and fitness widely seen in natural populations.
(© 2023 The Authors. Molecular Ecology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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