Sex differences in the relationship between platelet count and type 2 diabetes risk in community-dwelling adults: Longitudinal findings over 14 years.

Autor: Yun EK; Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Korea., Seo IH; Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Korea., Lee HS; Department of Research Affairs, Biostatistics Collaboration Unit, Yonsei University College of Medicines, Seoul, Korea., Seol SY; Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Korea., Lee YJ; Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Korea.
Jazyk: angličtina
Zdroj: Diabetes/metabolism research and reviews [Diabetes Metab Res Rev] 2023 Sep; Vol. 39 (6), pp. e3641. Date of Electronic Publication: 2023 Apr 11.
DOI: 10.1002/dmrr.3641
Abstrakt: Aims: Emerging evidence suggests that platelet count predicts the development of type 2 diabetes; however, there is conflicting evidence concerning the relationship in men and women. This study aimed to assess the longitudinal association between platelet count and the incidence risk of type 2 diabetes.
Materials and Methods: Among 10,030 participants, 7325 participants (3439 men and 3886 women) without diabetes were selected from the Korean Genome and Epidemiology Study. Platelet count quartiles were divided as follows: Q1 ≤219, Q2, 220-254, Q3, 255-296 and Q4 ≥297 (x10 3 /ml) for men and ≤232, 233-266, 267-305 and ≥306 (x10 3 /μL) for women. The hazard ratios (HRs) with 95% confidential intervals (CIs) for incident type 2 diabetes were calculated using multiple Cox proportional hazards regression models according to sex-specific platelet count quartiles.
Results: During the biennial follow-up period from 2001 to 2002 to 2013-2014, 750 male participants (21.8%, 750/3439) and 730 female participants (18.8%, 730/3886) had newly developed type 2 diabetes. For women, compared to the reference first quartile, the HRs for incident type 2 diabetes in the second, third, and fourth platelet count quartiles were 1.20 (0.96-1.50), 1.21(0.97-1.51), and 1.47 (1.18-1.82) after adjusting for age, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, family history of diabetes, and HOMA-IR. However, these positive relationships were not observed in men after adjusting for the same co-variables.
Conclusions: Platelet count was independently associated with an increased risk of incident type 2 diabetes only in women.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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