Current perspectives of mitochondria-targeted antioxidants in cancer prevention and treatment.
| Autor: | Zinovkin RA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.; The 'Russian Clinical Research Center for Gerontology' of the Ministry of Healthcare of the Russian Federation, Pirogov Russian National Research Medical University, Moscow, Russia., Lyamzaev KG; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.; The 'Russian Clinical Research Center for Gerontology' of the Ministry of Healthcare of the Russian Federation, Pirogov Russian National Research Medical University, Moscow, Russia., Chernyak BV; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in cell and developmental biology [Front Cell Dev Biol] 2023 Mar 16; Vol. 11, pp. 1048177. Date of Electronic Publication: 2023 Mar 16 (Print Publication: 2023). |
| DOI: | 10.3389/fcell.2023.1048177 |
| Abstrakt: | Oxidative stress nearly always accompanies all stages of cancer development. At the early stages, antioxidants may help to reduce reactive oxygen species (ROS) production and exhibit anticarcinogenic effects. In the later stages, ROS involvement becomes more complex. On the one hand, ROS are necessary for cancer progression and epithelial-mesenchymal transition. On the other hand, antioxidants may promote cancer cell survival and may increase metastatic frequency. The role of mitochondrial ROS in cancer development remains largely unknown. This paper reviews experimental data on the effects of both endogenous and exogenous antioxidants on cancerogenesis focusing on the development and application of mitochondria-targeted antioxidants. We also discuss the prospects for antioxidant cancer therapy, focusing on the use of mitochondria-targeted antioxidants. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Zinovkin, Lyamzaev and Chernyak.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|