Potential Prognostic and Predictive Role of Monocyte and Lymphocyte Counts on Presentation in Patients Diagnosed With Diffuse Large B-Cell Lymphoma.
| Autor: | Kharroubi DM; Clinical Pathology, Rafic Hariri University Hospital, Beirut, LBN., Nsouli G; Oncology, Rafic Hariri University Hospital, Beirut, LBN., Haroun Z; Obstetrics and Gynecology, Rafic Hariri University Hospital, Beirut, LBN. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Mar 01; Vol. 15 (3), pp. e35654. Date of Electronic Publication: 2023 Mar 01 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.35654 |
| Abstrakt: | Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin's lymphoma. Nearly 40% of patients will die of relapsed disease despite the use of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy. Many prognostic markers established in the chemotherapy era are no longer valid in the rituximab era. Objectives: We aim to identify whether we can add absolute lymphocyte count (ALC), absolute monocyte count (AMC), and lymphocyte-to-monocyte ratio (LMR) as new prognostic factors for DLBCL treated with R-CHOP. We also aim to find whether a correlation exists between these variables and the revised International Prognostic Index (R-IPI) score. Methods: This is an observational retrospective study done from 2005 to 2015 in Rafic Hariri University Hospital (RHUH), Lebanon, on 42 patients treated with R-CHOP. Patients' data were obtained from medical records. We used receiver operating characteristic (ROC) curve for establishing cutoff values. The chi-square test was used to analyze associations between variables. Results: Patients were followed for a median of 42 months (24-96 months). Patients with LMR < 2.53 had a significantly worse outcome than those with LMR ≥ 2.53 ( p < 0.0001). This was also true for patients with ALC < 1.47 × 10 9 /L ( p = 0.0163) and AMC > 0.603 × 10 9 /L ( p = 0.0053). LMR was also able to risk-stratify patients within each R-IPI category into high- and low-risk patients. Conclusion: ALC, AMC, and LMR, surrogate markers of the host immune system and tumor microenvironment, have prognostic significance in DLBCL patients treated with R-CHOP. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Kharroubi et al.) |
| Databáze: | MEDLINE |
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